Strattera
withdrawal. Strattera withdrawal side effects,
Strattera withdrawal warnings, Strattera withdrawal precautions, Strattera
withdrawal adverse effects, overdose, withdrawal symptoms and Strattera natural alternatives. Before you begin the spiral down with
Strattera, try giving your body what it really wants.
Strattera
(atomoxetine)
If you are suffering from Strattera side effects or
Strattera withdrawal side effects, there is an answer and a solution.
The common Strattera side effects of anxiety,
insomnia, fatigue, weight gain, or unwanted head feelings can usually be handled quickly.
Whether you want to taper completely off Strattera or
just eliminate the existing side effects caused by the Strattera, there is an
answer and a solution.
Click here and you will be
directed to The Road Back, which offers all of the information for free on their
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Did your doctor tell
you Strattera was really an antidepressant?
Strattera
withdrawal Body
Strattera
withdrawal
Dry Mouth
- The
usual amount to moisture in the mouth is noticeably less.
Strattera
withdrawal
Sweating
Increased -
A large
quantity of perspiration that is medically caused.
Strattera
withdrawal
Cardiovascular (Involving the heart and the blood
vessels)
Strattera
withdrawal
Palpitation
- Unusual and not normal heartbeat,
that is sometimes irregular, but rapid and forceful thumping or fluttering. It
can be brought on by shock, excitement, exertion, or medical stimulants. A
person is normally unaware of his/her heartbeat.
Strattera withdrawal
Hypertension
- is high blood pressure, which is a
symptom of disease in the blood vessels leading away from the heart.
Hypertension is known as the “silent killer”. The symptoms are usually not
obvious, however it can lead to damage to the heart, brain, kidneys and eye, and
even to stroke and kidney failure. Treatment includes dietary and lifestyle
changes.
Strattera withdrawal
Bradycardia
-
The heart rate is slowed from 72 beats per minute,
which is normal, to below 60 beats per minute in an adult.
Strattera
withdrawal
Tachycardia
- The heart rate is speeded up to
above 100 beats per minute in an adult. Normal adult heart rate is 72 beats per
minute.
Strattera
withdrawal
ECG Abnormal
-
A test
called an electrocardiogram (ECG) that records the activity of the heart. It
measures heartbeats as will as the position and size of the heart’s four
chambers. It also measures if there is damage to the heart and the effects of
drugs or mechanical devices like a pacemaker on the heart. When the test is
abnormal this means that one or more of the following are present: heart
disease, defects, beating too fast or too slow, disease of the blood vessels
leading from the heart or of the heart valves, and/or a past or about to occur
heart attack.
Strattera
withdrawal
Flushing
- The skin all over the body turns red.
Strattera withdrawal
Varicose Vein - Unusually swollen veins
near the surface of the skin that sometimes appear twisted and knotted, but
always enlarged. They are called hemorrhoids when they appear around the
rectum. The cause is attributed to hereditary weakness in the veins aggravated
by obesity, pregnancy, pressure from standing, aging, etc. Severe cases may
develop swelling in the legs, ankles and feet, eczema and/or ulcers in the
affected areas.
Strattera
withdrawal
Gastrointestinal
(Involving
the stomach and the intestines)
Strattera withdrawal
Abdominal Cramp/Pain
-
Sudden, severe, uncontrollable and painful shortening and
thickening of the muscles in the belly. The belly includes the stomach as well
as the intestines, liver, kidneys, pancreas, spleen, gall bladder, and urinary
bladder.
Strattera withdrawal
Belching
- Noisy release of gas from the stomach through the mouth; a burp.
Strattera
withdrawal
Bloating
- Swelling of the belly caused by excessive intestinal gas.
Strattera withdrawal
Constipation -
Difficulty in having a bowel movement where the material in the bowels is
hard due to a lack of exercise, fluid intake, and roughage in the diet, or due
to certain drugs.
Strattera withdrawal
Diarrhea - Unusually frequent and excessive, runny bowel movements that may
result in severe dehydration and shock.
Strattera
withdrawal
Dyspepsia - Indigestion. This is the discomfort you experience after eating. It
can be heartburn, gas, nausea, a bellyache or bloating.
Strattera withdrawal
Flatulence
- More gas than normal in the digestive organs.
Strattera withdrawal
Gagging
- Involuntary choking and/or involuntary throwing up.
Strattera withdrawal
Gastritis
- A severe irritation of the mucus lining of the stomach either short in
duration or lasting for a long period of time.
Strattera withdrawal
Gastroenteritis
-
A condition where the membranes
of the stomach and intestines are irritated.
Strattera
withdrawal
Gastroesophageal
Reflux - A
continuous state where stomach juices flow back into the throat causing acid
indigestion and heartburn and possibly injury to the throat.
Strattera
withdrawal
Heartburn
- A burning pain in the area of the breastbone caused by stomach juices flowing
back up into the throat.
Strattera withdrawal
Hemorrhoids - Small rounded
purplish swollen veins that either bleed, itch or are painful and appear around
the anus.
Strattera withdrawal
Increased Stool frequency
-
Diarrhea.
Strattera
withdrawal
Indigestion
- Unable to properly consume and absorb food in the digestive tract causing
constipation, nausea, stomach ache, gas, swollen belly, pain and general
discomfort or sickness.
Strattera withdrawal
Nausea - Stomach irritation with a queasy sensation similar to
motion sickness and a feeling that one is going to vomit.
Strattera
withdrawal
Polyposis Gastric
- Tumors that grow on stems in the lining of the stomach, which usually become
cancerous.
Strattera withdrawal
Swallowing Difficulty
- A feeling that food is stuck in the throat or upper chest area and won’t go
down, making it difficult to swallow.
Strattera withdrawal
Toothache
- Pain in a tooth above and below the gum line.
Strattera withdrawal
Vomiting
- Involuntarily throwing up the contents of the stomach and usually getting a
nauseated, sick feeling just prior to doing so.
Strattera
withdrawal
General
Strattera withdrawal
Allergy -
The extreme
sensitivity of body tissues triggered by substances in the air, drugs, or foods
causing a reaction like sneezing, itching, asthma, hay fever, skin rashes,
nausea and/or vomiting.
Strattera withdrawal
Anaphylaxis
- A violent, sudden, and severe drop
in blood pressure caused by a re-exposure to a foreign protein or a second
dosage of a drug that may be fatal unless emergency treatment is given right
away.
Strattera withdrawal
Asthenia
-
A physically
weak condition.
Strattera
withdrawal
Chest Pains
-
Severe discomfort in the chest caused by not enough oxygen going to the heart
because of narrowing of the blood vessels or spasms.
Strattera
withdrawal
Chills
-
Appearing
pale while cold and shivering; sometimes with a fever.
Strattera withdrawal
Edema of
Extremities
-
Abnormal
swelling of the body’s tissue caused by the collection of fluid.
Strattera withdrawal
Fall
- To suddenly lose your normal
standing upright position as if you were shot.
Strattera
withdrawal
Fatigue
- Loss of normal strength so as to
not be able to do the usual physical and mental activities.
Strattera
withdrawal
Fever
- Abnormally high body temperature,
the normal being 98 degrees Fahrenheit or 37 degrees Centigrade in humans, which
is a symptom of disease or disorder in the body. The body is affected by
feeling hot, chilled, sweaty, weak and exhausted. If the fever goes too high,
death can result.
Strattera
withdrawal
Hot Flashes
-
Brief,
abnormal enlargement of the blood vessels that causes a sudden heat sensation
over the entire body. Women in menopause will sometimes experience this.
Strattera
withdrawal
Influenza-like
Symptoms -
Demonstrating irritation of the respiratory tract (organs of breathing) such as
a cold, sudden fever, aches and pains, as well as feeling weak and seeking bed
rest, which is similar to having the flu.
Strattera
withdrawal
Leg Pain
- A
hurtful sensation in the legs that is caused by excessive stimulation of the
nerve endings in the legs and results in extreme discomfort.
Strattera withdrawal
Malaise -
The somewhat
unclear feeling of discomfort you get when you start to feel sick.
Strattera
withdrawal
Pain in Limb
-
Sudden, sharp and uncontrolled leg discomfort.
Strattera
withdrawal
Syncope
-
A short
period of light headedness or unconsciousness (black-out) also know as fainting
caused by lack of oxygen to the brain because of an interruption in blood
flowing to the brain.
Strattera withdrawal
Tightness of
Chest -
Mild or sharp discomfort, tightness
or pressure in the chest area (anywhere between the throat and belly). The
causes can be mild or seriously life-threatening because they include the heart,
lungs and surrounding muscles.
Strattera
withdrawal
Hemic and Lymphatic Disorders
(Involving
the blood and the clear fluids in the tissues that contain white blood cells)
Strattera withdrawal
Bruise
- Damage to the skin resulting in a
purple-green-yellow skin coloration that’s caused by breaking the blood vessels
in the area without breaking the surface of the skin.
Strattera
withdrawal
Anemia
-
A condition
where the blood is no longer carrying enough oxygen, so the person looks pale
and easily gets dizzy, weak and tired. More severely, a person can end up with
an abnormal heart, as well as breathing and digestive difficulties. The causes
of anemia are not enough protein in the red blood cells, or missing and
chemically destroyed red blood cells, as well as diseased or destroyed bone
marrow.
Strattera withdrawal
Nosebleed
- Blood lost from the part of the
face that has the organs of smell and is where the body takes in oxygen.
Strattera
withdrawal
Hematoma
- Broken blood vessels that cause a
swelling in an area on the body.
Strattera
withdrawal
Lymphadenopathy
Cervical
-
The lymph
nodes in the neck, which are part of the body’s immune system get swollen and
enlarge by reacting to the presence of a drug. The swelling is the result of
the white blood cells multiplying in order to fight the invasion of the drug.
Strattera
withdrawal
Metabolic and Nutritional Disorders
(Energy
and health)
Strattera
withdrawal
Arthralgia
-
Sudden sharp
nerve pain in one or more joints.
Strattera
withdrawal
Arthropathy
- Having joint disease or abnormal
joints.
Strattera
withdrawal
Arthritis
-
Painfully inflamed and swollen joints. The reddened
and swollen condition is brought on by a serious injury or shock to the body
either from physical or emotional causes.
Strattera
withdrawal
Back Discomfort
- Severe physical distress in the area from the neck to the pelvis along the
backbone.
Strattera withdrawal
Bilirubin Increased
- Bilirubin is a waste product of the breakdown
of old blood cells. Bilirubin is sent to the liver to be made water-soluble so
it can be eliminated from the body through emptying the bladder. A drug can
interfere with or damage this normal liver function creating liver disease.
Strattera withdrawal
Decreased Weight
- Uncontrolled and measured loss of heaviness or weight.
Strattera
withdrawal
Gout
- A severe arthritis condition that is caused by the dumping of a waste product
called uric acid in the tissues and joints. It can become worse and cause the
body to develop a deformity after going through stages of pain, inflammation,
severe tenderness, and stiffness.
Strattera withdrawal
Hepatic Enzymes Increased - An increase in the amount of paired liver proteins that
regulate liver processes causing a condition where the liver functions
abnormally.
Strattera withdrawal
Hypercholesterolemia
- Too much cholesterol in the blood cells.
Strattera
withdrawal
Hyperglycemia
- An unhealthy amount of sugar in the blood.
Strattera withdrawal
Increased Weight - A concentration and storage of fat in the body
accumulating over a period of time caused by unhealthy eating patterns, that can
predispose the body to many disorders and diseases.
Strattera withdrawal
Jaw Pain - The pain due to irritation and swelling of the nerves associated with
the mouth area where it opens and closes just in front of the ear. Some of the
symptoms are pain when chewing, head aches, losing your balance, stuffy ears or
ringing in the ears, and teeth grinding.
Strattera withdrawal
Jaw Stiffness
- The result of squeezing and grinding the teeth while asleep that can cause
your teeth to deteriorate as well as the muscles and joints of the jaw.
Strattera
withdrawal
Joint Stiffness
- A loss of free motion and easy flexibility where any
two bones come together.
Strattera withdrawal
Muscle Cramp - When muscles contract uncontrollably without warning and do not
relax. The muscles of any of the body’s organs can cramp.
Strattera
withdrawal
Muscle Stiffness
- Tightening of muscles making it difficult to bend.
Strattera
withdrawal
Muscle Weakness
- Loss of physical strength.
Strattera
withdrawal
Myalgia - A general widespread pain and tenderness of the muscles.
Strattera
withdrawal Thirst
- A strong,
unnatural craving for moisture/water in the mouth and throat.
Strattera
withdrawal
Nervous System (Sensory channels)
Strattera withdrawal
Carpal
Tunnel Syndrome - A
pinched nerve in the wrist that causes pain, tingling, and numbing.
Strattera withdrawal
Coordination Abnormal - A lack of normal, harmonious interaction of the parts of
the body when it is in motion.
Strattera withdrawal
Dizziness - Losing one’s balance while feeling unsteady and lightheaded which may
lead to fainting.
Strattera
withdrawal
Disequilibrium
- Lack of mental and emotional balance.
Strattera withdrawal
Faintness - A temporary condition where one is likely to go
unconscious and fall.
Strattera withdrawal
Headache - A sharp or dull persistent pain in the head
Strattera
withdrawal
Hyperreflexia - A not normal and involuntary increased response in the
tissues connecting the bones to the muscles.
Strattera
withdrawal
Light-headed
Feeling –
Uncontrolled and usually brief loss of consciousness caused by lack of oxygen to
the brain.
Strattera
withdrawal
Migraine
- Reoccurring severe head pain usually with nausea, vomiting, dizziness, flashes
or spots before the eyes, and ringing in the ears
Strattera withdrawal
Muscle Contractions Involuntary
- Spontaneous and uncontrollable tightening reaction of the muscles caused by
electrical impulses from the nervous system.
Strattera
withdrawal
Muscular Tone Increased - Uncontrolled and exaggeration muscle tension. Muscles are
normally partially tensed and this is what gives us muscle tone.
Strattera
withdrawal
Paresthesia - Burning, prickly, itchy, or tingling skin with no obvious or
understood physical cause.
Strattera withdrawal
Restless Legs
- A need to move the legs without any apparent reason. Sometimes there is pain,
twitching, jerking, cramping, burning, or a creepy-crawly sensation associated
with the movements. It worsens when a person is inactive and can interrupt
one’s sleep so one feels the need to move to gain some relief.
Strattera
withdrawal
Shaking
- Uncontrolled quivering and trembling as if one is cold and chilled.
Strattera
withdrawal
Sluggishness
- Lack of alertness and energy, as well as being slow to respond or perform in
life.
Strattera withdrawal
Tics - A contraction of a muscle causing a repeated movement not
under the control of the person usually on the face or limbs.
Strattera
withdrawal
Tremor
- A nervous and involuntary vibrating or quivering of the body.
Strattera withdrawal
Twitching - Sharp, jerky and spastic motion sometimes with a
sharp sudden pain.
Strattera
withdrawal
Vertigo
- A sensation of dizziness with disorientation and confusion.
Strattera
withdrawal Psychiatric Disorders (Mental and emotional)
Strattera withdrawal
Aggravated Nervousness
- A progressively worsening, irritated and troubled state of mind.
Strattera
withdrawal
Agitation
- Suddenly violent and forceful, emotionally disturbed state of mind.
Strattera withdrawal
Amnesia - Long term or short term, partial or full memory loss created by
emotional or physical shock, severe illness, or a blow to the head where the
person was caused pain and became unconsciousness.
Strattera
withdrawal
Anxiety Attack
- Sudden and intense feelings of fear, terror, and dread physically creating
shortness of breath, sweating, trembling and heart palpitations.
Strattera withdrawal
Apathy
- Complete lack of concern or interest for things that ordinarily would be
regarded as important or would normally cause concern.
Strattera
withdrawal
Appetite
Decreased - Having a
lack of appetite despite the ordinary caloric demands of living with a resulting
unintentional loss of weight.
Strattera
withdrawal
Appetite
Increased - An
unusual hunger causing one to overeat.
Strattera
withdrawal
Auditory
Hallucination -
Hearing things without the voices or noises being present.
Strattera
withdrawal
Bruxism -
Grinding and clenching of teeth while sleeping.
Strattera withdrawal
Carbohydrate
Craving - A drive
and craving to eat foods rich in sugar and starches (sweets, snacks and junk
foods) that intensifies as the diet becomes more and more unbalanced due to the
unbalancing of the proper nutritional requirements of the body.
Strattera withdrawal
Concentration Impaired
- Unable to easily focus your attention for long periods of time.
Strattera
withdrawal
Confusion
- Not able to think clearly and understand in order to make a logical decision.
Strattera
withdrawal
Crying Abnormal
- Unusual and not normal fits of weeping for short or long periods of time for
no apparent reason.
Strattera withdrawal
Depersonalization
- A condition where one has lost a normal sense of personal identity.
Strattera
withdrawal
Depression
- A hopeless feeling of failure, loss and sadness that can deteriorate into
thoughts of death.
Strattera
withdrawal
Disorientation
- A loss of sense of direction, place, time or surroundings as well as mental
confusion on personal identity.
Strattera
withdrawal
Dreaming Abnormal
- Dreaming that leaves a very clear, detailed picture and impression when awake
that can last for a long period of time and sometimes be unpleasant.
Strattera
withdrawal
Emotional
Lability
- Suddenly breaking out
in laughter or crying or doing both without being able to control the outburst
of emotion. These episodes are unstable as they are caused by things that
normally would not have this effect on an individual.
Strattera withdrawal
Excitability - Uncontrollably responding to stimuli.
Strattera withdrawal
Feeling Unreal - The awareness that one has an undesirable emotion like
fear but can’t seem to shake off the irrational feeling. For example, feeling
like one is going crazy but rationally knowing that it is not true. The quality
of this side effect resembles being in a bad dream and not being able to wake
up.
Strattera
withdrawal
Forgetfulness
- Unable to remember what one ordinarily would remember.
Strattera
withdrawal
Insomnia
- Sleeplessness caused by physical stress, mental stress or stimulants such as
coffee or medications; it is a condition of being abnormally awake when one
would ordinarily be able to fall and remain asleep.
Strattera
withdrawal
Irritability
- Abnormally annoyed in response to a stimulus.
Strattera withdrawal
Jitteriness - Nervous fidgeting without an apparent cause.
Strattera
withdrawal
Lethargy
- Mental and physical sluggishness and apathy that can deteriorate into an
unconscious state resembling deep sleep. A numbed state of mind.
Strattera
withdrawal
Libido Decreased
- An abnormal loss of sexual energy or desire.
Strattera withdrawal
Panic Reaction
- A sudden, overpowering, chaotic and confused mental state of terror resulting
in being doubt ridden often accompanied with hyperventilation, and extreme
anxiety.
Strattera
withdrawal
Restlessness
Aggravated - A
constantly worsening troubled state of mind characterized by the person being
increasingly nervous, unable to relax, and easily angered.
Strattera
withdrawal
Somnolence - Feeling sleepy all the time or having a condition of
semi-consciousness.
Strattera
withdrawal
Suicide Attempt
- An unsuccessful deliberate attack on one’s own life with the intention of
ending it.
Strattera
withdrawal
Suicidal Tendency
- Most likely will attempt to kill oneself.
Strattera withdrawal
Tremulousness
Nervous - Very
jumpy, shaky, and uneasy while feeling fearful and timid. The condition is
characterized by thoughts of dreading the future, involuntary quivering,
trembling, and feeling distressed and suddenly upset.
Strattera withdrawal
Yawning - involuntary opening of the mouth with deep inhalation of
air.
Strattera
withdrawal
Reproductive Disorder Female
Strattera
withdrawal
Breast Neoplasm
-
A tumor or cancer, of either of the two milk-secreting
organs on the chest of a woman.
Strattera
withdrawal
Menorrhagia
- Abnormally heavy menstrual period or a
menstrual flow that has continued for an unusually long period of time.
Strattera
withdrawal
Menstrual Cramps
- Painful, involuntary uterus contractions that women experience around the time
of their menstrual period, sometimes causing pain in the lower back and thighs.
Strattera
withdrawal
Menstrual
Disorder - A disturbance or derangement in the normal function of a woman’s
menstrual period.
Strattera
withdrawal
Pelvic
Inflammation - The reaction of the body to infectious, allergic, or chemical
irritation, which in turn causes tissue irritation, injury, or bacterial
infection characterized by pain, redness, swelling, and sometimes loss of
function. The reaction usually begins in the uterus and spreads to the
fallopian tubes, ovaries, and other areas
in the hipbone region of the body.
Strattera
withdrawal
Premenstrual
Syndrome - Various physical and mental symptoms commonly experienced by women of
childbearing age usually 2 to 7 days before the start of their monthly period.
There are over 150 symptoms including eating binges, behavioral changes,
moodiness, irritability, fatigue, fluid retention, breast tenderness, headaches,
bloating, anxiety, and depression. The symptoms cease shortly after the period
begins, and disappear with menopause.
Strattera
withdrawal
Spotting Between
Menses - Abnormal bleeding between periods. Unusual spotting
between menstrual cycles.
Strattera
withdrawal
RESPIRATORY SYSTEM
(Organs involved in breathing)
Strattera
withdrawal
Asthma
- A disease of the breathing system initiated by and allergic reaction
or a chemical with repeated attacks of coughing, sticky mucus, wheezing,
shortness of breath, and a tight feeling in the chest. The disease can reach a
state where it stops a person from exhaling, leading to unconsciousness and
death.
Strattera
withdrawal
Breath Shortness
-
Unnatural breathing using a lot off effort resulting in not enough air taken in
by the body.
Strattera
withdrawal
Bronchitis
- Inflammation of the two main
breathing tubes leading from the windpipe to the lungs. The disease is marked
with coughing, a low-grade fever, chest pains, and hoarseness, caused by an
allergic reaction.
Strattera
withdrawal
Coughing
- A cough is the response to an
irritation, such as mucus, that causes the muscles controlling the breathing
process to expel air from the lungs suddenly and noisily to keep the air
passages free from the irritating material.
Strattera
withdrawal
Laryngitis
- Inflammation of the voice box
characterized by hoarseness, sore throat, and coughing. It can be cause by
straining the voice or exposure to infectious, allergic or chemical irritation.
Strattera
withdrawal
Nasal Congestion
- The
presence of an abnormal amount of fluid in the nose.
Strattera
withdrawal
Pneumonia
Tracheitis - Bacterial infection of the air passageways and lungs that causes
redness, swelling and pain in the windpipe. Other symptoms are high fever,
chills, pain in the chest, difficulty in breathing, and coughing with mucus
discharge.
Strattera
withdrawal
Rhinitis
- Chemical irritation causing pain,
redness and swelling in the mucus membranes of the nose.
Strattera
withdrawal
Sinus Congestion
- The
mucus-lined areas of the bones in the face that are thought to help warm and
moisten air to the nose. These areas become clogged with excess fluid or
infected.
Strattera
withdrawal
Sinus Headache
- The
abnormal amount of fluid in the hollows of the face bone area especially around
the nose. This excess fluid creates pressure, causing pain in the head.
Strattera
withdrawal
Sinusitis
- The body reacting to chemical
irritation causing redness, swelling and pain in the area of the hollows in the
facial bones especially around the nose.
Strattera
withdrawal SKELETAL
Strattera withdrawal
Neck/Shoulder Pain
- Hurtful sensations
of the nerve endings caused by damage to the tissues in the neck and shoulder
signaling danger of disease.
Strattera
withdrawal
SKIN and APPENDAGES DISORDERS (Skin, legs and arms)
Strattera
withdrawal
Acne
- Eruptions of the oils glands of the
skin, especially on the face, marked by pimples, blackheads, whiteheads, bumps,
and more severely, by cysts and scarring.
Strattera withdrawal
Alopecia -
The loss of hair or baldness.
Strattera
withdrawal
Eczema
- A severe or continuing skin disease
marked by redness, crusting and scaling with watery blisters and itching. It is
often difficult to treat and will sometimes go away only to reappear again.
Strattera
withdrawal
Dermatitis
- Generally irritated skin that can
be caused by any of a number of irritating things such as parasites, fungus,
bacteria, or foreign substances
causing an allergic reaction. It is a general inflammation of the skin.
Strattera
withdrawal
Dry Lips
- The
lack of normal moisture in the fleshy folds that surround the mouth.
Strattera withdrawal
Dry Skin - The lack of normal moisture/oils in the
surface layer of the body. The skin is the body’s largest organ.
Strattera withdrawal
Folliculitis
-
Inflammation of a follicle (small body sac) especially a hair follicle. A hair
follicle contains the root of a hair.
Strattera withdrawal
Furunculosis - Skin boils that show up repeatedly.
Strattera withdrawal
Lipoma - A tumor of mostly fat cells that is not health
endangering.
Strattera withdrawal
Pruritus
- Extreme itching of often-undamaged skin.
Strattera withdrawal
Rash - A skin eruption or discoloration that may or may not be
itching, tingling, burning, or painful. It may be caused by an allergy, an skin
irritation, a skin disease.
Strattera withdrawal
Skin Nodule - A bulge, knob, swelling or outgrowth in the skin
that is a mass of tissue or cells.
Strattera withdrawal
SPECIAL SENSES
Strattera withdrawal
Conjunctivitis
- Infection of the membrane that covers the eyeball and lines the eyelid, caused
by a virus, allergic reaction, or an irritating chemical. It is characterized
by redness, a discharge of fluid and itching.
Strattera withdrawal
Dry Eyes - Not enough moisture in the eyes.
Strattera withdrawal
Earache - Pain in the ear.
Strattera withdrawal
Eye Infection
- The invasion of the eye tissue by a bacteria, virus, fungus, etc, causing
damage to the tissue, with toxicity. Infection spreading in the body progresses
into disease.
Strattera withdrawal
Eye Irritation
- An inflammation of the eye.
Strattera withdrawal
Metallic Taste
- A range of taste impairment from distorted taste to a complete loss of taste.
Strattera withdrawal
Pupils Dilated
- Abnormal expansion of the blace circular opening in the center of the eye.
Strattera withdrawal
Taste alteration
- Abnormal flavor detection in food.
Strattera withdrawal
Tinnitus - A buzzing, ringing, or whistling sound in one or
both ears occurring from the internal use of certain drugs.
Strattera withdrawal
Vision Abnormal
- Normal images are seen differently by the viewer.
Strattera withdrawal
Vision Blurred
- Eyesight is dim or indistinct and hazy in outline or appearance.
Strattera withdrawal
Visual Disturbance
- Eyesight is interfered with or interrupted. Some disturbances are light
sensitivity and the inability to easily distinguish colors.
Strattera
withdrawal URINARY SYSTEM
DISORDER
Strattera
withdrawal
Blood in Urine
-
Blood is present when one empties liquid waste product of the kidneys through
the bladder by urinating in the toilet turning the water pink to bright red. Or
you could see pots of blood in the water after urinating.
Strattera
withdrawal
Dysuria
- Difficult or painful urination.
Strattera
withdrawal
Kidney Stone
- Small hard masses of salt deposits that the kidney forms.
Strattera
withdrawal
Urinary Frequency - Having to urinate more often than usual or between unusually short
time periods.
Strattera
withdrawal
Urinary Tract
Infection - An invasion of bacteria, viruses, fungi, etc., of the
system in the body that starts with the kidneys and eliminates urine from the
body. If the invasion goes unchecked it can injure tissue and progress into
disease.
Strattera
withdrawal
Urinary Urgency
- A sudden compelling urge to urinate, accompanied by discomfort in the bladder.
Strattera
withdrawal
UROGENITAL (Urinary tract and genital structures or functions)
Strattera
withdrawal
Anorgasmia
- Failure to experience an orgasm.
Strattera
withdrawal
Ejaculation
Disorder - Dysfunction of the discharge of semen during orgasm.
Strattera
withdrawal
Menstrual
Disorder - Dysfunction of the discharge during the monthly menstrual cycle.
Strattera withdrawal
Acute Renal
Failure - The kidneys
stop functioning properly to excrete wastes.
Strattera withdrawal
Angioedema
- Intensely itching and swelling welts on the skin called hives caused by an
allergic reaction to internal or external agents. The reaction is common to a
food or a drug. Chronic cases can last for a long period of time.
Strattera
withdrawal
Toxic Epidermal
Necrolysis - An abnormal condition where a large portion of skin
becomes intensely red and peels off like a second-degree burn. Often the
symptoms include blistering.
Strattera
withdrawal
Gastrointestinal
Hemorrhage - Stomach and intestinal excessive internal bleeding.
Strattera withdrawal
Grand Mal
Seizures (or Convulsions)
- A recurring sudden violent and involuntary attack of muscle spasms with a loss
of consciousness.
Strattera withdrawal
Neuroleptic Malignant Syndrome
- A life threatening, rare reaction to an anti-psychotic drug marked by fever,
muscular rigidity, changed mental status, and dysfunction of the autonomic
nervous system.
Strattera withdrawal
Pancreatitis - Chemical irritation with redness, swelling, and
pain in the pancreas where digestive enzymes and hormones are secreted.
Strattera withdrawal
QT Prolongation
- A very fast heart rhythm disturbance that is too fast for the heart to beat
effectively so the blood to the brain falls causing a sudden loss of
consciousness and may cause sudden cardiac death.
Strattera withdrawal
Rhabdomyolysis
- The breakdown of muscle fibers that releases the fibers into the circulatory
system. Some of the fibers are poisonous to the kidney and frequently result in
kidney damage.
Strattera withdrawal
Serotonin Syndrome
- A disorder brought on by excessive levels of serotonin caused by drugs and can
be fatal as death from this side effect can come very rapidly.
Strattera withdrawal
Thrombocytopenia
- An abnormal decrease in the number of blood platelets in the circulatory
system. A decrease in platelets would cause a decrease in the ability of the
blood to clot when necessary.
Strattera withdrawal
Torsades de Pointes
- Unusual rapid heart rhythm starting in the lower heart chambers. If the short
bursts of rapid heart rhythm continue for a prolonged period it can degenerate
into a more rapid rhythm and can be fatal.
Strattera
withdrawal. How to avoid
Strattera withdrawal side
effects click here
FDA Talk Paper
T04-60
December 17, 2004 Media Inquiries: 301-827-6242
Consumer Inquiries: 888-INFO-FDA
New Warning for Strattera
The Food and Drug Administration (FDA) is advising
health care professionals about a new warning for Strattera, a drug approved for
attention deficit hyperactivity disorder (ADHD) in adults and children. The
labeling is being updated with a bolded warning about the potential for severe
liver injury following two reports (a teenager and an adult) in patients who had
been treated with Strattera for several months, both of whom recovered.
The labeling warns that severe liver injury may
progress to liver failure resulting in death or the need for a liver transplant
in a small percentage of patients. The labeling also notes that the number of
actual cases of severe liver injury is unknown because of under-reporting of
post-marketing adverse events.
The bolded warning indicates that the medication
should be discontinued in patients who developed jaundice (yellowing of the skin
or whites of the eyes) or laboratory evidence of liver injury.
Strattera has been on the market since 2002 and
has been used in more than 2 million patients. In clinical trials of 6000
patients, no signal for liver problems (hepatotoxicity) had emerged.
FDA has asked the manufacturer to add a bolded
warning about severe liver injury to the labeling. Eli Lilly has agreed to alert
health care professionals about the new information in a Dear Health
Professional letter. The company will also update the patient package insert
with information about the signs and symptoms of liver problems, which include:
- Pruritus (Itchy skin)
- Jaundice
- Dark urine
- Upper right-sided abdominal tenderness
- Or unexplained “flu-like” symptoms
Health care professionals are encouraged to
report any unexpected adverse events associated with Strattera directly to Eli
Lilly, Indianapolis, Ind., at 1800-LillyRx or to the FDA MedWatch program at
1800-FDA-1088. The MedWatch form is available online at
http://www.fda.gov/medwatch/safety/3500.pdf
for download by mail (or fax, 1800-FDA-0178) to MedWatch, HFD-410, FDA, 5600
Fishers Lane, Rockville, Md. 20857.
Strattera is really an antidepressant that Eli
Lilly could not find a market for in the early 1990's. Eli Lilly sat on the drug
until they came up with the idea of using it for ADHD. If you are giving
Strattera to your child or thinking about doing so, know you are really giving
them an antidepressant and all caution should be taken.
Before allowing your child to take Strattera,
please read down this page and pay special note to the bold text. We know
most parents would not give their child medication if they knew it would cause
more harm than good. We also understand the need for a parent to receive verifiable
information that is also reliable.
The Strattera information below is from the
Physicians' Desk Reference, supplied by Eli Lilly. Their report, not ours. We
are only evaluating their data.
At issue with Strattera as well as with the
class of antidepressants called SSRIs, is the metabolism and side effects.
Eli Lilly Employees - It is time for you to
come clean like many of the FDA scientist have done over the past month.
Children are the future of our civilization and you are killing them. You can
send me an e-mail that will be held in confidence if you wish.
Click here
STRATTERA™ (Lilly)
(atomoxetine HCl)
DESCRIPTION
STRATTERA™ (atomoxetine HCl) is a selective norepinephrine reuptake
inhibitor. Atomoxetine HCl is the R (-) isomer as determined by x-ray
diffraction. The chemical designation is (-)- N -methyl-3-phenyl-3-( o
-tolyloxy)-propylamine hydrochloride. The molecular formula is C 17 H
21 NO•HCl, which corresponds to a molecular weight of 291.82.
CLINICAL PHARMACOLOGY
Pharmacodynamics and Mechanism of Action
The precise mechanism by which atomoxetine produces its therapeutic
effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but
is thought to be related to selective inhibition of the pre-synaptic
norepinephrine transporter, as determined in ex vivo uptake and
neurotransmitter depletion studies. (Editors note - Eli
Lilly admits upfront this is guess work)
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Test
Human Pharmacokinetics
Atomoxetine is well-absorbed after oral administration and is minimally
affected by food. It is eliminated primarily by oxidative metabolism through
the cytochrome P450 2D6 (CYP2D6) enzymatic pathway and subsequent
glucuronidation. Atomoxetine has a half-life of about 5 hours. A fraction of
the population (about 7% of Caucasians and 2% of African Americans) are poor
metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced
activity in this pathway resulting in 10-fold higher AUCs, 5-fold higher peak
plasma concentrations, and slower elimination (plasma half-life of about 24
hours) of atomoxetine compared with people with normal activity [extensive
metabolizers (EMs)]. Drugs that inhibit CYP2D6, such as fluoxetine, paroxetine,
and quinidine, cause similar increases in exposure. (Editors
note - If your child is a poor metabolizer, the half life or how long the drug
stays in the system is 10 fold that of normal metabolizer plus the peak
concentration of Strattera is 5 fold higher)
The pharmacokinetics of atomoxetine have been evaluated in more than 400
children and adolescents in selected clinical trials, primarily using population
pharmacokinetic studies. Single-dose and steady-state individual pharmacokinetic
data were also obtained in children, adolescents, and adults. When doses were
normalized to a mg/kg basis, similar half-life, C max , and AUC
values were observed in children, adolescents, and adults. Clearance and volume
of distribution after adjustment for body weight were also similar.
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Test
Absorption and Distribution --Atomoxetine is rapidly absorbed after
oral administration, with absolute bioavailability of about 63% in EMs and 94%
in PMs. Maximal plasma concentrations (C max ) are reached
approximately 1 to 2 hours after dosing.
Metabolism and Elimination --Atomoxetine is metabolized primarily
through the CYP2D6 enzymatic pathway. People with reduced activity in this
pathway (PMs) have higher plasma concentrations of atomoxetine compared with
people with normal activity (EMs). For PMs, AUC of atomoxetine is approximately
10-fold and C ss,max is about 5-fold greater than EMs. Laboratory
tests are available to identify CYP2D6 PMs. Coadministration of
STRATTERA with potent inhibitors of CYP2D6, such as fluoxetine, paroxetine, or
quinidine, results in a substantial increase in atomoxetine plasma exposure, and
dosing adjustment may be necessary. Atomoxetine did not inhibit or induce
the CYP2D6 pathway. (Editors note - Eli Lilly finally is
admitting there is a test that can determine this)
Back to top of page Metabolism
Test
The major oxidative metabolite formed, regardless of CYP2D6 status, is
4-hydroxyatomoxetine, which is glucuronidated. 4-Hydroxyatomoxetine is
equipotent to atomoxetine as an inhibitor of the norepinephrine transporter but
circulates in plasma at much lower concentrations (1% of atomoxetine
concentration in EMs and 0.1% of atomoxetine concentration in PMs).
4-Hydroxyatomoxetine is primarily formed by CYP2D6, but in PMs,
4-hydroxyatomoxetine is formed at a slower rate by several other cytochrome P450
enzymes. N-Desmethylatomoxetine is formed by CYP2C19 and other cytochrome P450
enzymes, but has substantially less pharmacological activity compared with
atomoxetine and circulates in plasma at lower concentrations (5% of atomoxetine
concentration in EMs and 45% of atomoxetine concentration in PMs).
Mean apparent plasma clearance of atomoxetine after oral administration in
adult EMs is 0.35 L/hr/kg and the mean half-life is 5.2 hours. Following oral
administration of atomoxetine to PMs, mean apparent plasma clearance is 0.03
L/hr/kg and mean half-life is 21.6 hours. For PMs, AUC of atomoxetine is
approximately 10-fold and C ss,max is about 5-fold greater than EMs.
The elimination half-life of 4-hydroxyatomoxetine is similar to that of N-desmethylatomoxetine
(6 to 8 hours) in EM subjects, while the half-life of N-desmethylatomoxetine is
much longer in PM subjects (34 to 40 hours). (Editors note
- The difference here in half life for poor metabolizer is 34-40 hours vs. 6-8
hours. We are talking days difference. If you are still taking Strattera on top
of this, imagine what is happening inside the body)
Back to top of page Metabolism
Test
Atomoxetine is excreted primarily as 4-hydroxyatomoxetine- O -glucuronide,
mainly in the urine (greater than 80% of the dose) and to a lesser extent in the
feces (less than 17% of the dose). Only a small fraction of the STRATTERA dose
is excreted as unchanged atomoxetine (less than 3% of the dose), indicating
extensive biotransformation.
Drug-Drug Interactions
CYP2D6 activity and atomoxetine plasma concentration --Atomoxetine is
primarily metabolized by the CYP2D6 pathway to 4-hydroxyatomoxetine. In EMs,
inhibitors of CYP2D6 increase atomoxetine steady-state plasma concentrations to
exposures similar to those observed in PMs. Dosage adjustment of STRATTERA in
EMs may be necessary when coadministered with CYP2D6 inhibitors, e.g.,
paroxetine, fluoxetine, and quinidine. In vitro studies suggest that
coadministration of cytochrome P450 inhibitors to PMs will not increase the
plasma concentrations of atomoxetine.
Effect of atomoxetine on P450 enzymes --Atomoxetine did not cause
clinically important inhibition or induction of cytochrome P450 enzymes,
including CYP1A2, CYP3A, CYP2D6, and CYP2C9.
Albuterol --Albuterol (600 mcg iv over 2 hours) induced increases in
heart rate and blood pressure. These effects were potentiated by atomoxetine (60
mg BID for 5 days) and were most marked after the initial coadministration of
albuterol and atomoxetine.
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Metabolism
Test
Alcohol --Consumption of ethanol with STRATTERA did not change the
intoxicating effects of ethanol.
Desipramine --Coadministration of STRATTERA (40 or 60 mg BID for 13
days) with desipramine, a model compound for CYP2D6 metabolized drugs (single
dose of 50 mg), did not alter the pharmacokinetics of desipramine. No dose
adjustment is recommended for drugs metabolized by CYP2D6.
Methylphenidate --Coadministration of methylphenidate with STRATTERA
did not increase cardiovascular effects beyond those seen with methylphenidate
alone.
Midazolam --Coadministration of STRATTERA (60 mg BID for 12 days) with
midazolam, a model compound for CYP3A4 metabolized drugs, (single dose of 5 mg),
resulted in 15% increase in AUC of midazolam. No dose adjustment is recommended
for drugs metabolized by CYP3A.
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Test
Precautions
In pediatric placebo-controlled trials, STRATTERA-treated
subjects experienced a mean increase in heart rate of about 6 beats/minute
compared with placebo subjects. At the final study visit before drug
discontinuation, 3.6% (12/335) of STRATTERA-treated subjects had heart rate
increases of at least 25 beats/minute and a heart rate of at least 110
beats/minute, compared with 0.5% (1/204) of placebo subjects. No pediatric
subject had a heart rate increase of at least 25 beats/minute and a heart rate
of at least 110 beats/minute on more than one occasion. Tachycardia was
identified as an adverse event for 1.5% (5/340) of these pediatric subjects
compared with 0.5% (1/207) of placebo subjects. The mean heart rate increase
in extensive metabolizer (EM) patients was 6.7 beats/minute, and in poor
metabolizer (PM) patients 10.4 beats/minute.
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Test
Laboratory Tests
Routine laboratory tests are not required.
CYP2D6 metabolism --Poor metabolizers (PMs) of CYP2D6 have a
10-fold higher AUC and a 5-fold higher peak concentration to a given dose of
STRATTERA compared with extensive metabolizers (EMs). Approximately 7% of a
Caucasian population are PMs. Laboratory tests are available to identify CYP2D6
PMs. The blood levels in PMs are similar to those attained by taking strong
inhibitors of CYP2D6. The higher blood levels in PMs lead to a higher rate of
some adverse effects of STRATTERA. (Eli Lilly admits a
higher rate of adverse reaction if you are a poor metabolizer)
Back to top of page Metabolism
Test
CYP2D6 inhibitors --Atomoxetine is primarily metabolized by the CYP2D6
pathway to 4-hydroxyatomoxetine. In EMs, selective inhibitors of CYP2D6 increase
atomoxetine steady-state plasma concentrations to exposures similar to those
observed in PMs. Dosage adjustment of STRATTERA may be necessary when
coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and
quinidine. In EM individuals treated with paroxetine or fluoxetine, the AUC of
atomoxetine is approximately 6- to 8-fold and C ss,max is about 3- to
4-fold greater than atomoxetine alone.
Child and Adolescent Clinical Trials
Reasons for discontinuation of treatment due to adverse events in child
and adolescent clinical trials --In acute child and adolescent
placebo-controlled trials, 3.5% (15/427) of atomoxetine subjects and 1.4%
(4/294) placebo subjects discontinued for adverse events. For all |