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Sleep. Sleep apnea, sleep disorder, sleep aids, go to
sleep, sleep apnia, sleep medication, sleep problem, sleep treatment. Sleep. The
solution for problem sleep, sleep apnea, sleep disorder, and other sleep
problems. Don't lose another night without sleep.
Sleep
The reports of people using
the Body calm and or Body Calm Supreme for sleep are amazing. Many are stating "They have not slept
like this since a child."
People that were having vivid
dreams, nightmares, restless night sleep are also stating, "Those nights have
just left."
Note: The
cherry as a sleep aid is very different than a sleeping pill you might be
accustomed to. It does not make your drowsy before going to sleep. You lay down
at night as normal, shut your eyes and calmly just go to sleep.
Additional stories
are coming in with Body Calm. People suffering from anxiety during the day are
using this Body Calm every 3-4 hours and all are stating how it just calms them
down and the anxiety goes a way.
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Read more below.
Being able to sleep is a
problem for many, not just by people taking a medication. In fact, many people
are prescribed a medication because of their inability to sleep. We know,
without sleep our body will eventually die.
The effect on us, or our body,
with a continued reduction of sleep can cause stress, anxiety and depression as
well as real tangible physical malfunctions.
It is wildly known and accepted
Melatonin plays a major role in sleep patterns. Clinical trials number 11,339
that study Melatonin, as of this date at
www.pubmed.gov. This is
not new science or a new body of knowledge. Melatonin promotes sleep, the
desired sleep.
Getting Melatonin through a
capsule form is questionable. A timed-release version of Melatonin is the only
capsule source that has ever shown any success but it has not for every
individual.
I always strive to recommend
supplements that will make the body work or manufacture its own vitamins,
nutrients or amino acids whenever possible. Having a body receive the right diet
or combination of nutrients will jumpstart the body to start producing once
again what it should be doing naturally.
I would be the first to admit
that many of the nutrients I have found, that actually worked, shocked me.
Looking at or for a nutrient that would promote sleep through the body’s natural
process is no different.
Montmorency
Tart Cherries have been scientifically proven to promote Melatonin in a quantity
needed to have therapeutic benefit. The clinical trials that have been conducted
speak for themselves.
I have
supplied clinical trials and other validated information regarding Melatonin as
well as Montmorency Tart Cherries clinical trials.
This
concentrated cherry drink gets rid of free radicals as well. You should have a
look at a chart. You might just think as I did at first, "What is all this about
a cherry concentrate?" And I was very wrong. This is a very potent product.
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How to use
this product for sleep:
-
Start
by taking 1/2 teaspoon 2 hours or less before bedtime.
-
After 1
week, if you are not sleeping as you need, take 1 teaspoon 2 hours or
less before bedtime. You can slowly move up to the recommended dosage of 1-2
tablespoons a day but I do recommend you do it gradually.
-
When
you wake in the morning, if you feel groggy, reduce the amount of supplement
by 1/2. You should be resting fully all night and waking up fresh in the
morning with the right amount of melatonin in the body.
-
Mix in
8-10 oz of water or juice. Do not mix in grapefruit juice. Grapefruit
blocks specific liver enzymes that should not be blocked if using an
antidepressant.
The
evidence is clear. Click here to read why I recommend
the specific nutrients or supplements.
I will
place a link between the sections below for a source for
Montmorency Tart Cherries in a
natural concentrated form. You take the concentrate with water.
click here
Body Calm.
Montmorency
Tart Cherries are perhaps nature’s most nutritionally dense food containing a
wide variety of powerful antioxidants and phyto-chemicals unmatched by any other
fruit, as measured by the scientifically validated ORAC method.
In fact
each serving contains a whopping 5,286 ORAC units! ORAC is an
acronym for Oxygen Radical Absorbance Capacity (the ability to scavenge free
radicals). According to researchers at the Human Aging Institute, ingesting
5000 ORAC units per day substantially reduces your risk of coronary heart
disease, cancer, and other age related illnesses. Additionally Tart Montmorency
Cherry Juice Concentrate contains melatonin that helps balance circadian rhythms
(for proper sleep), plus anti-inflammatory saccharides that may assist the body
to relieve the pain associated with arthritis and gout, as well as perillyl
alcohol (a natural compound that is extremely powerful in
reducing the incidence of all types of cancer). Not to mention
isoqueritrin and queritrin (anthocyanins that work to
eliminate the by-products of oxidative stress thereby slowing the aging
process), and ellagic acid (Clinical tests
conducted at the Hollings Cancer Institute at the Medical University of Southern
Carolina (MUSC) shows that ellagic acid may be the most potent way to prevent
cancer). These cherries are truly nature’s most powerful combination of
cell rejuvenating antioxidants!
Testimonial:
This
product has had a major impact on my life! I am finally sleeping well. Must be
the Melatonin! I used to wake, off and on, all night. Now my head hits the
pillow, I fall asleep, and don't wake until the alarm goes off. I am certain
that this better quality of sleep is what is responsible for my improved mood
during the day. I have recommended cherry juice to MANY of my friends. If their
results are half as good as mine, they will be very happy!" Laura
from Kentucky
Noni, goji
berry, mangosteen simply cannot compare! If you want to give your body the most
potent fruit juice we could find, discover “Body Calm”, you will LOVE IT!
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High Quantity of Melatonin
Identified in Tart Cherries
The
University of Texas Health Science Center recently began to quantify the
availability and activity of the Melatonin in cherry products. Melatonin is a
potent antioxidant for which there is extensive evidence showing it to be
significant in improving the body's circadian rhythms and natural sleep
patterns. Melatonin is rapidly absorbed by the body, and it is predicted that
eating just a handful of cherries will increase melatonin levels in the blood,
thereby improving the body's natural sleep patterns.
Scientists have discovered high levels (13.5 ng/g) of the
antioxidant melatonin in Montmorency tart cherries.
In addition to its antioxidative properties, melatonin, has
been shown to possess anti-inflammatory properties.
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Cancer-Fighter Perillyl Alcohol
Found in Tart Cherries
Research at the University of Iowa is showing the amazing properties of
cherries. According to Raymond Holm, M.D. at the University of Iowa, tart
cherries contain perillyl alcohol (POH), a natural compound that is extremely
powerful in reducing the incidence of all types of cancer. Perillyl alcohol
"shuts down the growth of cancer cells by depriving them of the proteins they
need to grow," explains Dr. Hohl. "It works on every kind of cancer we've tested
it against."
Independent Lab Verifies
Cancer Fighting Agents in Tart Cherries
Researchers at Brunswick Laboratories (Wareham, Mass.) verified the natural
antioxidants present in Montmorency tart cherries, the leading U.S. tart cherry
variety, will be available for use in products soon. Lead researcher Dr. Boxin
Ou also confirmed the presence of substantial quantities of melatonin. He also
identified two important flavonoids -- isoqueritrin and queritrin -- and
documented the presence of ellagic acid in cherries.
Ellagic acid is a natural occurring plant phenolic that is
known as a potent anti-carcinogenic/anti-mutagenic compound. Clinical tests
conducted at the Hollings Cancer Institute at the Medical University of Southern
Carolina (MUSC) shows that ellagic acid may be the most potent way to prevent
cancer.
The flavonoids -- isqueritrin and queritrin -- act as
antioxidants as do the anthocyanins. They work to eliminate by-products of
oxidative stress and thereby slow the aging process.
**From the Cherry Marketing Institute
Michigan State University
First to Identify Anthocyanins in Tart Cherries
"Twenty
cherries provide 25 mg of anthocyanins which help shut down the enzymes that
cause tissue inflammation in the first place, so cherries can prevent and treat
many kinds of pain", states Dr. Nair, Michigan State University Researcher.
Anthocyanins are plant pigments responsible for the bright red color of
cherries. These pigments are known to have antioxidant activity and antioxidants
are believed to play a role in reducing the risk of various human degenerative
diseases. Tart cherries contain anthocyanins and flavonoids, which inhibit the
enzymes and prevent inflammation in the body. These compounds have similar
activity as aspirin, naproxen, and ibuprofen. The anthocyanins may also protect
artery walls from the damage that leads to plaque buildup and heart disease.
Recent studies show that anthocyanins do a better job of protecting arteries
than vitamins C and E.
There are 17 antioxidants in tart cherries. Two of these,
anthocyanins 1 and 2, can inhibit the cyclooxygenase (COX) enzymes, which are
associated with the pain of arthritis and gout. In comparison of 10 small
fruits, cherries had the highest level of anthocyanins 1 and 2. Anthocyanins 1
and 2 are NOT present in blueberries or cranberries.
**From the Cherry Marketing Institute
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Melatonin
What's
new on MELATONIN?
As we grow older we produce less and less melatonin. Also, if
there is some sort of trauma in our lives at any time we do not produce as much
Melatonin. This could have a great deal to do with why people are not sleeping
well. Perhaps it is more than stress. It is because they are not producing
enough Melatonin to tell them that it is time to sleep. Tart Cherry Juice
Concentrate is loaded with Melatonin.
Dr. Russell Reiter, University of Texas Health Science
Center, is said to be the Dean of Melatonin Research and he gives cherries high
marks. We were surprised at how much Melatonin was in cherries, specifically the
Montmorency variety, says Reiter. And Tart Cherry Juice Concentrate, which
involves greatly reducing the water content, has ten times the Melatonin of the
raw fruit. Tart Cherries contain an extremely significant quantity of melatonin,
enough to produce positive results in the body.
Montmorency cherries, which account for the majority of tart
cherries produced in the United States, contain up to 13.5 nanograms (ng) of
melatonin per gram of cherries, more than is normally found in the blood.
Melatonin is by far the most potent of the antioxidants, much more so than
vitamins C, E and A. The reason: melatonin is soluble both in fat and water and
can therefore enter some cells that vitamins cannot. For example, vitamin E is
soluble in the lipid part of the cell only and vitamin Compounds (called
limonenes) are used as food additives and are found in the blood. Melatonin is
by far the potent of the antioxidants, much more so than vitamins C, E, and A.
The reason: melatonin is soluble both in fat and water and can therefore enter
some cells that vitamins cannot. For example, vitamin E is soluble in the lipid
part of the cell only and vitamin C in the aqueous part. Melatonin is soluble in
both. For this reason, Dr. Reiter says, eating cherries with high melatonin
concentrations will increase the antioxidant capacity in the body.
**From the Cherry Marketing Institute's
Cherry Advantage Issue #3 December 2002.
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Antioxidants
Researchers at Brunswick Laboratories (Wareham, MA) verified the natural
antioxidants present in Montmorency tart cherries. Lead researcher Dr. Boxin Ou
also identified two important flavonoids: isoqueritrin and queritrin. These
antioxidants work to eliminate by-products of oxidative stress and thereby slow
the aging process.
He also documented the presence of ellagic acid in cherries.
Ellagic acid is a naturally occurring plant phenolic that is known as a potent
anti-carcinogenic/antimutagenic compound. Clinical tests conducted at the
Hollings Cancer Institute at the Medical University of South Carolina show that
ellagic acid may be the most potnet way to prevent cancer. It also may inhibit
the growth of cancer cells and arrest the growth of cancer in subjects with a
genetic predisposition for the disease.
**From the Cherry Marketing Institute's
Cherry Advantage Issue #1 December 2000.
Tart Cherry Anthocyanins
Inhibit Tumor Development
New
studies at Michigan State University (MSU), which were recently published in
Cancer Letters, suggest that tart cherries may reduce the risk of colon cancer
because of the anthocyanins and cyanidin contained in the cherry. Dr.
Mauraleedharan Nair and Dr. Leslie Bourguin along with several graduate students
worked on experiments that are part of ongoing research on the components of
tart cherries.
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Improvement of sleep
quality by controlled-release melatonin in benzodiazepine-treated elderly
insomniacs.
Garfinkel D, Laudon M, Zisapel N.
Aging Research, Day Care Unit, The E. Wolfson Medical Center, Holon 58100 and
Meonot Maccabi, 7 Hanna Senech St., Bat-Yam 59303, Israel.
Benzodiazepines are widely used in the elderly population for the initiation of
sleep. However, very frequently, complaints about poor sleep maintenance persist
despite benzodiazepine treatment. Melatonin, a hormone produced by the pineal
gland at night, is involved in the regulation of the sleep/wake cycle. Melatonin
production decreases with age and can also be inhibited by benzodiazepines. We
have recently reported on the association between insomnia and impaired
melatonin output in the elderly. In the present study we have investigated the
efficacy of melatonin replacement therapy in improving sleep in 21 elderly
subjects who have been taking benzodiazepines and had low melatonin output. In a
randomized, double-blind, crossover designed study the subjects were treated for
three weeks with 2 mg per night of controlled-release melatonin and for 3 weeks
with placebo, 2 h before desired bedtime with a 1-week washout period between
treatment periods. Subjects' sleep was assessed by wrist actigraphy. Melatonin
treatment significantly increased sleep efficiency and total sleep time and
decreased wake after sleep onset, sleep latency, number of awakenings and
fragmental index, as compared to placebo. The results of our study indicate that
melatonin replacement therapy can improve sleep quality in the elderly and that
the beneficial effects are augmented in the presence of benzodiazepines.
PMID: 15374128 [PubMed - in process]
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Polysomnographic study
of the effect of melatonin on sleep in elderly patients with chronic primary
insomnia.
Monti JM, Alvarino F, Cardinali D, Savio I, Pintos A.
Department of Pharmacology and Therapeutics, Clinics Hospital, Av. Italia s/n,
J. Zudanez 2833/602, Montevideo, 11300, Uruguay.
The effect of 3-mg melatonin capsules p.o. on sleep in ten elderly patients
suffering from chronic primary insomnia was assessed by polysomnographic
recordings. In general, melatonin significantly reduced wake time after sleep
onset and increased total sleep time and sleep efficiency during the 2-week
treatment period. In five of the ten patients treated with melatonin, the
increase in total sleep time was clinically significant. Side effects were
absent during the period of drug administration. A slight increase of power
density in the delta and the theta regions was found during the early phase
(i.e. nights 4-5) of melatonin administration, whereas the opposite changes were
observed at a late phase of treatment (i.e. nights 15-16). No strict correlation
was found between prior 6-sulphatoxymelatonin levels in urine and subsequent
sleep improvement after receiving melatonin. Our results further support the
proposal that melatonin is beneficial for sleep disturbances in elderly
insomniacs.
PMID: 15374088 [PubMed - in process]
'A child with severe night terrors and sleep-walking
responds to melatonin therapy'.
Jan JE, Freeman RD, Wasdell MB, Bomben MM.
Publication Types:
·
Letter
PMID: 15540644 [PubMed - in process]
Melatonin therapy for circadian rhythm sleep disorders in children with multiple
disabilities: what have we learned in the last decade?
Dev Med Child Neurol. 2004
Nov;46(11):776-82. No abstract available.
PMID: 15540640 [PubMed - in process]
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Systematic review of melatonin treatment in children
with neurodevelopmental disabilities and sleep impairment.
Phillips L, Appleton RE.
Department of Neurology, Royal Liverpool Children's NHS Trust, Liverpool L12
2AP, UK.
Sleep disturbances in children with neurodevelopmental disabilities are common
and frequently difficult to treat with conventional pharmacological and
behavioural methods. Melatonin is a pineal hormone known to be important in the
regulation of the circadian rhythm, including the sleep-wake cycle. This
systematic review of available evidence from randomized clinical trials assesses
whether melatonin plays a beneficial role in these children and, in particular,
its effect on total sleep time, time to sleep onset (sleep latency), and number
of awakenings. We also looked at a parental view of the effect. Randomized
clinical trials were identified where oral melatonin was compared with a placebo
in children with any type of neurodevelopmental disability and associated sleep
disturbance. Only three studies, reporting a total of 35 children, fulfilled the
criteria for inclusion. The two studies that reported time to sleep onset showed
a significant decrease (p<0.05) in this specific outcome where melatonin was
compared with a placebo. There was no significant effect of melatonin compared
with a placebo on the other outcome measures of total sleep time, night-time
awakenings, and parental opinions. Despite the extremely limited randomized
clinical trial data, melatonin appears to remain a commonly prescribed drug for
disturbed sleep in children with neurodevelopmental abnormalities.
PMID: 15540639 [PubMed - in process]
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Different criteria of sleep latency and the effect of
melatonin on sleep consolidation.
Pinto LR Jr, Seabra Mde L, Tufik S.
Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo,
Brazil. luciano@psicobio.epm.br
OBJECTIVES: Since there is no consensus definition of sleep onset, we studied
different aspects of initial sleep periods in healthy volunteers taking
melatonin. Two criteria for sleep latency were used: 10 minutes of uninterrupted
sleep and 1.5 minutes of stage 1 sleep. PARTICIPANTS: Forty healthy male
volunteers (mean age 28 +/- 5 years) were assigned to 2 groups: 30 ingested
melatonin and 10 placebo. DESIGN: All volunteers underwent an initial
polysomnogram (baseline) after a 1-night adaptation period. The next day, the
placebo or a 10-mg dose of melatonin was administered for 28 days, 1 hour before
sleep time, in double-blind fashion. The second polysomnogram was recorded on
day 14. SETTING: Sleep laboratory RESULTS: Chronic melatonin administration led
to a significant reduction in sleep latency, using only the criterion 10 minutes
of uninterrupted sleep. This effect suggests that melatonin may have a hypnotic
effect, and the use of melatonin may lead to better sleep consolidation.
CONCLUSIONS: These results show differences that have clinical implications,
since the criteria used to diagnose initial insomnia were based on sleep onset.
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Melatonin advances the circadian timing of EEG sleep and directly
facilitates sleep without altering its duration in extended sleep opportunities
in humans.
Rajaratnam SM, Middleton B, Stone BM, Arendt J, Dijk DJ.
School of Psychology, Psychiatry and Psychological Medicine, Monash University,
Building 18, Victoria 3800, Australia. shantha.rajaratnam@med.monash.edu.au.
The rhythm of plasma melatonin originating from the pineal gland and driven by
the circadian pacemaker located in the suprachiasmatic nucleus is closely
associated with the circadian (approximately 24 h) variation in sleep propensity
and sleep spindle activity in humans. We investigated the contribution of
melatonin to variation in sleep propensity, structure, duration and EEG activity
in a protocol in which sleep was scheduled to begin during the biological day,
i.e. when endogenous melatonin concentrations are low. The two 14 day trials
were conducted in an environmental scheduling facility. Each trial included two
circadian phase assessments, baseline sleep and nine 16 h sleep opportunities
(16.00-08.00 h) in near darkness. Eight healthy male volunteers (24.4 +/- 4.4
years) without sleep complaints were recruited, and melatonin (1.5 mg) or
placebo was administered at the start of the first eight 16 h sleep
opportunities. During melatonin treatment, sleep in the first 8 h of the 16 h
sleep opportunities was increased by 2 h. Sleep per 16 h was not significantly
different and approached asymptotic values of 8.7 h in both conditions. The
percentage of rapid eye movement (REM) sleep was not affected by melatonin, but
the percentage of stage 2 sleep and sleep spindle activity increased, and the
percentage of stage 3 sleep decreased. During the washout night, the
melatonin-induced advance in sleep timing persisted, but was smaller than on the
preceding treatment night and was consistent with the advance in the endogenous
melatonin rhythm. These data demonstrate robust, direct sleep-facilitating and
circadian effects of melatonin without concomitant changes in sleep duration,
and support the use of melatonin in the treatment of sleep disorders in which
the circadian melatonin rhythm is delayed relative to desired sleep time.
PMID: 15459246 [PubMed - as supplied by publisher]
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Detection and
quantification of the antioxidant melatonin in Montmorency and Balaton tart
cherries (Prunus cerasus).
Burkhardt S, Tan DX, Manchester LC, Hardeland R, Reiter RJ.
Department of Cellular and Structural Biology, University of Texas Health
Science Center, Mail Code 7762, 7703 Floyd Curl Drive, San Antonio, Texas
78229-3900, USA.
The antioxidant melatonin was recently identified in a variety of edible plants
and seeds in high concentrations. In plants, as in animals, melatonin is
believed to function as a free radical scavenger and possibly in photoperiodism.
In this study, melatonin was detected and quantified in fresh-frozen Balaton and
Montmorency tart cherries (Prunus cerasus) using high-performance liquid
chromatography. Both cherry species contain high levels of melatonin compared to
the melatonin concentrations in the blood of mammals. Montmorency cherries
(13.46 +/- 1.10 ng/g) contain approximately 6 times more melatonin than do
Balaton cherries (2.06 +/- 0.17 ng/g). Neither the orchard of origin nor the
time of harvest influenced the amount of melatonin in fresh cherries. The
implication of the current findings is that consuming cherries could be an
important source of dietary melatonin inasmuch as melatonin is readily absorbed
when taken orally. Also, previously published data and the results presented
here show that melatonin is not only endogenously produced but also present in
the diet.
PMID: 11600041 [PubMed - indexed for MEDLINE]
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Tart cherry
anthocyanins suppress inflammation-induced pain behavior in rat.
Tall JM, Seeram NP, Zhao C, Nair MG, Meyer RA, Raja SN.
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins
Hospital, 600 North Wolfe Street, Osler 292, Baltimore, MD 21287, USA.
The use of complementary and alternative medicine (CAM) has increased in the
United States and more patients are seeking CAM therapies for control of pain.
The present investigation tested the efficacy of orally administered
anthocyanins extracted from tart cherries on inflammation-induced pain behavior
in rats. Paw withdrawal latency to radiant heat and paw withdrawal threshold to
von Frey probes were measured. The first set of experiments examined the effects
of tart cherry anthocyanins (400 mg/kg) on the nociceptive behaviors and edema
associated with inflammation induced by intraplantar injection of 1% carrageenan.
These studies also included tests of motor coordination. The second set of
experiments determined if tart cherry anthocyanins (15, 85, and 400 mg/kg)
dose-dependently affected the inflammation induced by intraplantar injection of
25% complete Freund's adjuvant. We found that tart cherry extracts reduce
inflammation-induced thermal hyperalgesia, mechanical hyperalgesia and paw
edema. The suppression of thermal hyperalgesia was dose-dependent and the
efficacy of highest dose (400 mg/kg) was similar to indomethacin (5 mg/kg). The
highest dose anthocyanin (400 mg/kg) had no effects on motor function. These
data suggest that tart cherry anthocyanins may have a beneficial role in the
treatment of inflammatory pain. The antihyperalgesic effects may be related to
the anti-inflammatory and antioxidant properties of anthocyanins. A better
understanding of the modulatory role of dietary constituents and phytonutrients
on pain will offer further therapeutic options for treating patients with
persistent and chronic pain conditions.
PMID: 15219719 [PubMed - indexed for MEDLINE]
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Tart cherry
anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation
of human colon cancer cells.
Kang SY, Seeram NP, Nair MG, Bourquin LD.
Department of Food Science and Human Nutrition, Michigan State University, 139 G
M Trout Building, East Lansing, MI 48824-1224, USA.
Anthocyanins, which are bioactive phytochemicals, are widely distributed in
plants and especially enriched in tart cherries. Based on previous observations
that tart cherry anthocyanins and their respective aglycone, cyanidin, can
inhibit cyclooxygenase enzymes, we conducted experiments to test the potential
of anthocyanins to inhibit intestinal tumor development in Apc(Min) mice and
growth of human colon cancer cell lines. Mice consuming the cherry diet,
anthocyanins, or cyanidin had significantly fewer and smaller cecal adenomas
than mice consuming the control diet or sulindac. Colonic tumor numbers and
volume were not significantly influenced by treatment. Anthocyanins and cyanidin
also reduced cell growth of human colon cancer cell lines HT 29 and HCT 116. The
IC(50) of anthocyanins and cyanidin was 780 and 63 microM for HT 29 cells,
respectively and 285 and 85 microM for HCT 116 cells, respectively. These
results suggest that tart cherry anthocyanins and cyanidin may reduce the risk
of colon cancer.
PMID: 12706854 [PubMed - indexed for MEDLINE]
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Cyclooxygenase
inhibitory and antioxidant cyanidin glycosides in cherries and berries.
Seeram NP, Momin RA, Nair MG, Bourquin LD.
Department of Horticulture and National Food Safety and Toxicology Center,
Michigan State University, East Lansing 48824, USA.
Anthocyanins from tart cherries, Prunus cerasus L. (Rosaceae) cv. Balaton and
Montmorency; sweet cherries, Prunus avium L. (Rosaceae); bilberries, Vaccinum
myrtillus L. (Ericaceae); blackberries, Rubus sp. (Rosaceae); blueberries var.
Jersey, Vaccinium corymbosum L. (Ericaceae); cranberries var. Early Black,
Vaccinium macrocarpon Ait. (Ericaceae); elderberries, Sambucus canadensis (Caprifoliaceae);
raspberries, Rubus idaeus (Rosaceae); and strawberries var. Honeoye, Fragaria x
ananassa Duch. (Rosaceae), were investigated for cyclooxygenase inhibitory and
antioxidant activities. The presence and levels of cyanidin-3-glucosylrutinoside
1 and cyanidin-3-rutinoside 2 were determined in the fruits using HPLC. The
antioxidant activity of anthocyanins from cherries was comparable to the
commercial antioxidants, tert-butylhydroquinone, butylated hydroxytoluene and
butylated hydroxyanisole, and superior to vitamin E, at a test concentration of
125 microg/ml. Anthocyanins from raspberries and sweet cherries demonstrated 45%
and 47% cyclooxygenase-I and cyclooxygenase-II inhibitory activities,
respectively, when assayed at 125 microg/ml. The cyclooxygenase inhibitory
activities of anthocyanins from these fruits were comparable to those of
ibuprofen and naproxen at 10 microM concentrations. Anthocyanins 1 and 2 are
present in both cherries and raspberry. The yields of pure anthocyanins 1 and 2
in 100 g Balaton and Montmorency tart cherries, sweet cherries and raspberries
were 21, 16.5; 11, 5; 4.95, 21; and 4.65, 13.5 mg, respectively. Fresh
blackberries and strawberries contained only anthocyanin 2 in yields of 24 and
22.5 mg/100 g, respectively. Anthocyanins 1 and 2 were not found in bilberries,
blueberries, cranberries or elderberries.
PMID: 11695879 [PubMed - indexed for MEDLINE]
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From the
National Institutes of Health
What Is Sleep Apnea?
Sleep apnea is a common disorder that can be very
serious.
In sleep apnea, your breathing stops or gets very shallow while you are
sleeping. Each pause typically lasts 10-20 seconds or more. These pauses can
occur 20 to 30 times or more an hour.
The most common type of sleep apnea is obstructive sleep apnea. During sleep,
enough air cannot flow into your lungs through your mouth and nose even though
you try to breathe. When this happens, the amount of oxygen in your blood may
drop. Normal breaths then start again with a loud snort or choking sound.
Your sleep is not restful because:
- These brief episodes of increased airway resistance (and breathing
pauses) occur many times
- You may have many brief drops in your oxygen levels of the blood.
- You move out of deep sleep and into light sleep several times during the
night, resulting in poor sleep quality.
When your sleep is upset throughout the night, you can be very sleepy during the
day.
- People with sleep apnea often have loud snoring. However, not everyone
who snores has sleep apnea. Some people with sleep apnea don't know they
snore.
- Sleep apnea happens more often in people who are overweight, but even
thin people can have it.
- Most people don't know they have sleep apnea. They don't know that they
are having problems breathing while they are sleeping.
- A family member and/or bed partner may notice the signs of sleep apnea
first.
Untreated sleep apnea can increase the chance of having high blood pressure and
even a heart attack or stroke. Untreated sleep apnea can also increase the risk
of diabetes and the risk for work-related accidents and driving accidents.
| Consult with a health-care practitioner if you have any preexisting
medical conditions, including high blood pressure, heart or thyroid
problems, nervous disorders, diabetes, or are taking any prescription
drug. |
|
| Before beginning any program of
weight loss, consult your health care practitioner. These statements have
not been evaluated by the FDA. These
products are not intended to diagnose, treat, cure or prevent any disease. |
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