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Whey protein Questions and Answers about Immunocal®
and Immunepro RX
™.
The whey proteins Immunocal®
and Immunepro RX
™
both increase intracellular levels of glutathione. Compare the two whey
proteins.
Whey
Proteins
Glutathione
Once you read the information
below, if you are wanting to increase intracellular glutathione and you
wish to use RenewPro, come back to the top of this page and
click here.
(This site does not sell RenewPro.)
When it
comes to whey proteins and the creation of intracellular levels of
glutathione, there are two main choices using a whey protein. We review both whey proteins below.
The two whey proteins we compare are
Immunocal® and RenewPro®.
Conclusion - The
Renew Pro ™ is not only lower in price but offers a whey protein designed
to provide the amino acids needed to create intracellular glutathione in
greater abundance and is from hormone FREE cows.
Immunocal® patents were with a whey protein
concentrate. It is now a whey protein isolate. So, I am afraid the PDR
information may not be as accurate as hoped.
"The
whey protein concentrate (WPC) marketed as Immunocal has been tested in
hundreds of laboratory experiments..."
Click here for source. The is from their own Web Site.
I have spoken with
Immunotec's product development team and they did state
Immunocal® has been refined over the years and has been
improved beyond the original patent. I do not doubt that but any claim
being made of Immunocal from their earlier patents or clinical trials
with a whey concentrate should be disregarded.
ImmunePro RX™
PDR Drug information for
IMMUNOCAL® (Immunotec)
Immunepro RX
™
Whey Protein Products
Immunocal®
Click here
RenewPro
"The Finest Biologically Active
Protein
Naturally Contains
The Highest Levels of Undenatured Lactoferrin, Immunoglobulins,
Active Peptides and Growth Factors.
Traditionally, even the most
expensive dietary whey products have been the by-products of cheese
production with definite limitations in preserving the complete
biological activity of the whey proteins. The milk goes through a
heating process (HTST [High Temperature Short Time]
pasteurized [163° F, 30 seconds]), chemical modification and pH
regulation to produce cheese. Each of these steps denatures
(damages) the whey proteins. The denatured proteins are then
filtered out and what remains is the undenatured proteins that have
survived the processing. Some of these whey products are then
referred to as cold process/undenatured.
Back to top of page
RenewPro
whey protein concentrate is a Primary Product, not a
by-product. There is no cheese produced in any part of the
manufacturing process. It is the result of years of work to perfect
a system that produces only the highest quality milk whey protein.
The process uses no chemical modification or pH regulation in the
milk or whey production. The original milk proteins are intact
and undenatured. The result is a superior product that contains
exceptional amounts of the following important whey proteins
including the vital protein bound fats that whey protein isolates
remove.
RenewPro is made from milk
that is Hormone Treatment Free *
The serving size is 5 grams, one
scoop. 60 servings per container.
o Lactoferrin
- 120 milligrams*
per 5 grams.
an iron-binding, iron-modulating protein that enhances iron
absorption when needed, also anti-viral, anti-bacterial and
anti-inflammatory properties.
o Immunoglobulins -
520 milligrams*
per 5 grams.
contains numerous immune system benefits.
o Bovine Serum
Albumin - along with Lactoferrin and
Immunoglobulins contains generous amounts of Cysteine and
Glutamine, precursors in Glutathione (GSH)
production.
o
Active Peptides - (specialized paired amino acids),
exhibit a beneficial information transfer factor effect on the
immune system as well as boosting intracellular Glutathione.
o Growth
Factors - (growth promoting protein fractions) are
contained within the protein bound fats. Their function is to:
Regenerate all aged or injured cells in the body. Build and
retain muscle. Burn fat for fuel. Repair DNA and RNA. Fight
infections. Help regulate blood sugar and brain chemicals.
RenewPro is more potent by
far than any other whey product available
Click here to view report*
Undenatured Protein is ESSENTIAL for a
Vital Immune System
Back to top of page
| Active Protein Fractions* |
per 5 grams
|
|
Lactoferrin
3.4% |
125 mg
|
|
Immunoglobulins(IgG)16.1% |
520 mg
|
| Serum Albumin 2.5% |
|
|
alpha-lactalbumin
48.0% |
|
|
beta-lactoglobulin
13.7% |
|
* As determined
by an independent laboratory using the SDS PAGE Gel method.
Our Whey
Protein Concentrate contains the
Highest Levels of the Most Beneficial Protein Fractions.
The full range of biologically
active proteins in RenewPro play a major role in:
The repair of RNA and DNA, antioxidant production (Glutathione
precursors), improved liver function and red blood cell
production, the binding and safe removal of heavy metals, wound
healing, growth of new muscle and the support of various immune
functions.
* The milk for IRenewPro and
all of these exclusive whey protein products is from herds that
graze on disease-free, pesticide-free, chemical free, natural
grass pastures and the milking cows are not subject to any
chemicals, hormones, antibiotics, genetically modified
organisms, hyperimmunization or injected pathogens. They do not
ingest any unnatural man-made substances. There is no history of
bovine disease with the milk cows or dairy. The cows have never
been fed any imported food or cannibalistic by-products.
ImmunePro Rx is used daily by well-respected doctors in this
country.
Back to top of page
PDR Drug information
for
IMMUNOCAL® (Immunotec)
2003
NUTRACEUTICAL
(Bonded cysteine supplement)
Powder Sachets
IMMUNOCAL® is a U.S. patented natural
food protein concentrate in the FDA category of GRAS (generally
recognized as safe) which assists the body in maintaining optimal
concentrations of glutathione (GSH) by supplying the precursors required
for intracellular glutathione synthesis. It is clinically proven to
raise glutathione values (Lands et al, 1999).
Glutathione is a tripeptide made
intracellularly from its constituent amino acids L-glutamate, L-cysteine
and glycine. The sulfhydryl (thiol) group (SH) of cysteine serves as a
proton donor and is responsible for the biological activity of
glutathione. Provision of this amino acid is the rate-limiting factor in
glutathione synthesis by the cells since cysteine is relatively rare in
foodstuffs and furthermore, if released as the free amino acid, is toxic
and spontaneously catabolized in the gastrointestinal tract and blood
plasma.
Immunocal® is a bovine whey protein
isolate specially prepared so as to provide a rich source of
bioavailable cysteine. Following digestion, the cysteine remains as the
stable form cystine (2 molecules of cysteine linked by disulfide bond)
and glutamylcystine. After absorption, these dipeptides travel safely in
the blood stream and readily enter the cells to release free cysteine
for intracellular glutathione synthesis. Immunocal® can thus be viewed
as a cysteine delivery system.
The disulphide bond in cystine is pepsin
and trypsin resistant but may be split by heat, low pH or mechanical
stress releasing free cysteine. When subject to heat or shearing forces
(inherent in most extraction processes), the fragile disulfide bonds
within the peptides are broken and the bioavailablility of cysteine is
greatly diminished.
Glutathione is a tightly regulated
intracellular constituent and is limited in its production by negative
feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine
synthetase, thus greatly minimizing any possibility of overdosage.
Glutathione has multiple functions:
- It is the major endogenous
antioxidant produced by the cells, participating directly in the
neutralization of free radicals and reactive oxygen compounds, as
well as maintaining exogenous antioxidants such as vitamins C and E
in their reduced (active) forms.
- Through direct conjugation, it
detoxifies many xenobiotics (foreign compounds) and carcinogens,
both organic and inorganic.
- It is essential for the immune
system to exert its full potential, e.g. (1) modulating antigen
presentation to lymphocytes, thereby influencing cytokine production
and type of response (cellular or humoral) that develops, (2)
enhancing proliferation of lymphocytes thereby increasing magnitude
of response, (3) enhancing killing activity of cytotoxic T cells and
NK cells, and (4) regulating apoptosis, thereby maintaining control
of the immune response.
- It plays a fundamental role in
numerous metabolic and biochemical reactions such as DNA synthesis
and repair, protein synthesis, prostaglandin synthesis, amino acid
transport and enzyme activation. Thus, every system in the body can
be affected by the state of the glutathione system, especially the
immune system, the nervous system, the gastrointestinal system and
the lungs.
IMMUNOCAL® is a natural food supplement
and as such is limited from stating medical claims per se. Statements
have not been evaluated by the FDA. As such, this product is thus not
intended to diagnose, cure, prevent or treat any disease.
CONTRAINDICATIONS
IMMUNOCAL® is contraindicated in
individuals who develop or have known hypersensitivity to specific milk
proteins.
Each sachet of IMMUNOCAL® contains nine
grams of protein. Patients on a protein-restricted diet need to take
this into account when calculating their daily protein load. Although a
bovine milk derivative, IMMUNOCAL® contains less than 1% lactose and
therefore is generally well tolerated by lactose-intolerant individuals.
WARNINGS
Patients undergoing immunosuppressive
therapy should discuss the use of this product with their health
professional.
ADVERSE REACTIONS
Gastrointestinal bloating and cramps if
not sufficiently rehydrated. Transient urticarial-like rash in rare
individuals undergoing severe detoxification reaction. Rash abates when
product intake stopped or reduced. Back to top of page
OVERDOSAGE
Overdosing on IMMUNOCAL® has not been
reported.
DOSAGE AND ADMINISTRATION
For mild to moderate health challenges,
20 grams per day is recommended. Clinical trials in patients with AIDS,
COPD, cancer and chronic fatigue syndrome have used 30-40 grams per day
without ill effect. IMMUNOCAL® is best administered on an empty stomach
or with a light meal. Concomitant intake of another high protein load
may adversely affect absorption.
RECONSTITUTION
IMMUNOCAL® is a dehydrated powdered
protein isolate. It must be appropriately rehydrated before use. Remains
bioactive up to 12 hours after mixing. DO NOT heat or use a hot liquid
to rehydrate the product. DO NOT use a high-speed blender for
reconstitution. These methods will decrease the activity of the product.
Proper mixing is imperative. Consult
instructions included in packaging.
HOW SUPPLIED
10 grams of bovine milk protein isolate
powder per sachet.
30 sachets per box.
STORAGE
Store in a cool dry environment.
Refrigeration is not necessary.
Patent no.'s: 5,230,902 - 5,290,571 -
5,456,924 - 5,451,412 - 5,888,552
REFERENCES
- Baruchel S, Viau G, Olivier R. et
al. Nutraceutical modulation of glutathione with a humanized native
milk serum protein isolate, Immunocal®: application in AIDS and
cancer. In : Oxidative Stress in Cancer, AIDS and
Neurodegenerative Diseases. Ed.; Montagnier L, Olivier R, Pasquier
C. Marcel Dekker Inc. New York, 447-461, 1998
- Bounous G, Kongshavn P. Influence of
protein type in nutritionally adequate diets on the development of
immunity. In Absorption and Utilization of Amino Acids
Vol.II. Ed. M. Friedman. CRC Press, Inc., Fla. 2:219-32, 1989
- Bounous G, Gold P. The biological
activity of undenatured whey proteins: role of glutathione. Clin
Invest Med 14:296-309, 1991
- Bounous G, Baruchel S, Falutz J.
Gold P. Whey proteins as a food supplement in HIV-seropositive
individuals. Clin Invest Med. 16:3; 204-209, 1992
- Bounous G. Whey protein concentrate
(WPC) and glutathione modulation in cancer treatment. Anticancer
Res. 20:4785-4792,2000
- Bounous G. Immunoenhancing
properties of undenatured milk serum protein isolate in HIV
patients. Int. Diary Fed: Whey: 293-305, 1998
- Droge W, Holm E. Role of cysteine
and glutathione in HIV infection and other diseases associated with
muscle wasting and immunological dysfunction. FASEB J:
11(13):1077-1089, 1997
- Herzenberg LA, De Rosa SC, Dubs JG
et al. Glutathione deficiency is associated with impaired survival
in HIV disease. Proc Natl Acad Sci 94:1967-72,1997
- Kennedy R, Konok G, Bounous G et
al.. The use of a whey protein concentrate in the treatment of
patients with metastatic carcinoma: A phase 1-II clinical study.
Anticancer Res. 15:2643-50,1995
- Lands LC, Grey VL, Smountas AA.
Effect of supplementation with a cysteine donor on muscular
performance. J. Appl. Physiol. 87:1381-1385, 1999
- Locigno R, Castronovo V. Reduced
glutathione System: Role in cancer development, prevention and
treatment. International Journal of Oncology 19:221-236, 2001
- Lomaestro B, Malone M. Glutathione
in health and disease: pharmacotherapeutic issues. Ann Pharmacother
29: 1263-73,1995
- Lothian B, Grey V, Kimoff RJ, Lands.
Treatment of obstructive airway disease with a cysteine donor
protein supplement: a case report. Chest 117:914-916, 2000
- Meister A. Glutathione. Ann Rev
Biochem 52:711-60,1983
- Peterson JD, Herzenberg LA, Vasquez
KK, Waltenbaugh C. Glutathione levels in antigen-presenting cells
modulate Th1 versus Th2 response patterns. Proc.Natl. Acad. Sci.
95:3071-3076, 1998
- Watanabe A, Higachi K, Yasumura S.
et al. Nutritional modulation of glutathione level and cellular
immunity in chronic hepatitis B and C. Hepatology. 24:597A, 1996
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