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Review by Dr. Hyla Cass M.D. Psychiatrist "Here is an essential handbook on how to safely and more easily wean yourself (under medical supervision) off the heavily over-prescribed psychotropic medications. I have used the program with my patients and it works!” Hyla Cass M.D. Author of   Supplement Your Prescription The latest edition of How to  Get Off Psychotropic Drugs  Safely, is now available as an  e-book and at Amazon.com.  This bestselling book details  what to do to avoid Prozac  withdrawal side effects, what  you can do to eliminate  existing Prozac withdrawal  side effects and how to  reduce the Prozac safely.  Click here for the E-book  which allows you to receive  the book instantly! 
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Physician’s Resource The physician’s psychoactive medication resource guide 25% of your patients taking an antidepressant will have weight gain and the weight gain is directly caused by the antidepressant.
What is Glutathione? Glutathione is a small molecule made up of three amino acids, which exist in almost every cell of the body. The humand bodyhas been able to produce glutathione for centuries without vitamin supplements or our species would have died off years ago.
Glutathione. What is glutathione, how is glutathione made and how to safely increase glutathione levels answered on the Web Site. Glutathione used to treat toxicity, acne, cancer, HIV, allergies, Alzheimer's disease, cystic fibrosis, diabetes, hepatitis, liver dysfunction and more. This site has come up at the top of search engines for the past 10 years with the term glutathione for a simple reason. We were one of the first investigating glutathione when others were still wondering how to spell the word glutathione. What is Glutathione Glutathione is a small molecule made up of three amino acids, which exists in almost every cell of the body. The human body has been able to produce glutathione for centuries without vitamin supplements or our species would have died off years ago if the body did not have enough glutathione for survival. The presence of glutathione is required to maintain the normal function of the immune system. It is known to play a critical role in the multiplication of lymphocytes (the cells that mediate specific immunity) which occurs in the development of an effective immune response. Furthermore, the cells of the immune system produce many oxiradicals as a result of their normal functioning, resulting in a need for higher concentrations of antioxidants than most cells. Glutathione plays a crucial role in fulfilling this requirement. Why do we have such a wide variety of mental disorders, autism, Alzheimer’s, Parkinson’s, obesity, anxiety, stress, insomnia, hormone imbalance, bipolar disorder, cancer, diabetes, chronic fatigue, fibromyalgia, toxicity from heavy metals like mercury, lead etc., and other conditions in the 21 st  century? Is the only reason low levels of glutathione? Most of us do need to increase our glutathione levels, because of the above conditions, but is there a factor that is more underlying than glutathione? There is a gene in the body called the JNK gene that is the underlying problem with low levels of glutathione in all parts of the body, including the brain. The JNK Gene The JNK gene is a regulator type of gene and if it is too active or over stimulated, the JNK gene will allow the body to be flooded with toxins. The JNK gene is divided in 3 parts, JNK1, JNK 2 and JNK 3. JNJ 1 and JNK2 will affect all parts of the body except the brain and JNK 3 is a pathway activator of toxins to the brain. Several things will over activate the JNK gene. To name but a few things that over activate the JNK gene; antidepressants, heavy metals, processed foods, and viruses.  
If the JNK gene is over active, glutathione will need to work overtime and will be low in allparts of the body continually. If the JNK gene were balanced and no longer over stimulated, glutathione would have a chance to remain constant and handle the toxins in the body with ease once again.To make things a little more complex, low levels of glutathione will also stimulate the over activation of the JNK gene. This gives a compounding effect on the body regarding toxins.The goal should be to address the underlying cause of low glutathione levels and bring the JNK gene back in balance once again. Once this happens, a person will probably be able to create enough glutathione from their diet alone. Bring back the JNK gene in balance again and see if you do not lose weight, experience an improvement in mood, memory, brightness, less stressful feelings, sleep better and more. You can actually increase glutathione levels and reduce the activation of the JNK gene at the same time by using a supplement called JNK. Click here. You can also click here and read an interesting article regarding the JNK gene and the role JNK plays in glutathione. The author is on to something. If you are only interested in increasing glutathione levels, please continue reading or continue your search on other web sites. How to Make Glutathione Naturally Within the Body There are several ways a body can manufacture glutathione. It is true it takes 3 amino acids for the body to manufacture glutathione but our bodies can take food, turn the foods into the substance to manufacture the 3 needed amino acids needed to manufacture glutathione. This is also the natural method for a body to create glutathione. As an example, asparagus and watermelon will make glutathione. Eat your veggies and your body will make glutathione. With all of the breaking news regarding glutathione as an antioxidant as well as part of the reason for the development of autism, many supplements manufacturers are suddenly jumping on the glutathione bandwagon. Glutathione is not new to this Web Site. We have been recommending glutathione for the past 10 years to assist individuals to taper off psychotropic medications. One thing that has been overlooked by many is the role of glutathione within the liver as well as the role of glutathione transporting a toxin to the liver. There is considerable more to glutathione than having it in the cells. Increasing intracellular levels of glutathione is critical with drug withdrawal and it is vitally important that any supplement not cause a drug/supplement interaction. The human body has been able to make glutathione naturally forever and has not needed a whey protein or any other substance, other than food, since the beginning of time. Sometimes, an overload of toxins will create the need for an increase of glutathione for the body to balance itself again in a short amount of time. The time it takes to balance the body is the problem for some people. If glutathione remains too low and a continual stream of toxins are poured into the body there is a very good chance the body will need some help. There is so much hype about glutathione products by supplement companies and most of that hype is simply not true. The non-essential amino acid homocysteine is produced in the body with the metabolism of the amino acid methionine. Homocysteine is usually broken down into the amino acid cysteine. Cysteine is one of the amino acids needed by the cells to make intracellular glutathione. If your body does not convert homocysteine to cysteine the intracellular glutathione conversion will not take place.The rapid conversion of homocysteine is critical. If conversion takes place too slow, homocysteine will accumulate in the body and damage cell membranes, damage blood vessels, increase the risk of cardiovascular disease, and atherosclerosis. Rapid conversion of homocysteine requires an individual to have adequate amount of vitamin B6, B12, and folate. Over 50% of the population in the world has a genetic defect in the pathway needed to metabolize B6, B12, and folate. The site mentioned above, www.trbhealth.com also has a sublingual vitamin B6, B12 and folate. Metabolism of homocysteine (sulphur-containing amino acid) is accomplished in the remethylation cycle where vitamin B12 and folic acid are essential coenzymes and degraded to methionine or through transsulfuration, which use as cofactors folate, vitamin B6 and vitamin B12 and is degraded to cystathionine. The physician can check for hyperhomocysteine (higher than normal amount of homocysteine) with a blood test. Many medication side effects, physiological symptomology and other body and mental symptoms can be eliminated with treatment with vitamins B6, B12 and folate. Age is a factor of B6, B12 and folate metabolism despite an individuals DNA. With age, the enzyme needed to metabolize B6, B12 and folate will be depleted and the need to supplement through nutrition increases proportionally. High levels of homocysteine will be toxic on cells that line the arteries which will make the blood prone to clotting and promote bad cholesterol (LDL) which will be deposited as plaque in blood vessels. Cysteine helps to detoxify toxins and protect the body from radiation damage. Cysteine as well as selenium work hand in hand with vitamin E. Cysteine also needs selenium to be effective. Cysteine will bind with soluble iron, chelates heavy metals, and breaks down mucus in the respiratory tract, beneficial for bronchitis, emphysema, and tuberculosis. Of note: Cysteine as a stand-alone supplement should be avoided due to toxicity. Glutathione - Recap Cysteine is the pre-cursor to glutathione, the body’s natural antioxidant. Glutathione regulates the antioxidant redox state, and allows the body to recycle its store of antioxidants including: vitamin A, C, E and Co-enzyme Q10. Free cysteine is unstable and is readily oxidized producing compounds that could have harmful effects. Glutathione cannot be absorbed by cells and so must be re-synthesized intracellularly. Glutathione is the antioxidant that is prevalent in every cell in the human body. Glutathione is primarily synthesized in the liver where it is abundantly present. 80-90% of the blood that leaves the stomach and intestines passes through the liver. The blood carries important nutrients to the liver where they are metabolized into substances vital to life. In the same way, exogenous toxic substances reach the liver where they are either activated or transformed into less toxic derivatives. Glutathione plays a crucial role in the liver’s biotransformation system. The liver biotransformation system comprises important functions: 1.Filtering alcohol and other toxic substances from the blood. 2.Processing drugs and medications absorbed through the digestive system, enabling the body to use them effectively and ultimately dispose of them. The liver uses glutathione to process; alcohol, caffeine, medications, nicotine as an example, to process such substances and remove them from the blood. Cysteine is the limiting factor in glutathione synthesis, ensuring an adequate supply of glutathione helps cleanse the blood of toxins and substances. The role of glutathione and its inter-workings with alcohol and the metabolism has received the attention of scientist for years. With alcohol metabolism using the P 450 enzymes, much of the alcohol studies can be transformed into applicable knowledge with antidepressants and other medications that use the same system. Ethanol and Glutathione Reduced glutathione plays a critical role in the cellular detoxification processes including the metabolism of peroxides, the conjugation with electrophils and the scavenging of the free radicals. The relevance of glutathione in ethanol metabolism consists mainly in compensating for alcohol-related oxidative stress. Oxidative stress is a disturbance in the pro- oxidant/antioxidant balance (increased pro-oxidant levels), which may be achieved by either an enhancement of oxidative reactions leading to the increased formation of reactive oxygen species (ROS) or by a decrease of the antioxidant defense. Whether you are working with alcohol or most medications, both will activate the microsomal Cytochrome P450-dependant enzyme system, especially the subclass CYP2E1, that plays an important role in the liver detoxification. With antidepressants it will usually be with the subclass CYP2D6 or the CYP2C9 pathways. Glutathione (GSH) will be depleted within the cells and liver and also in other organs in the body due to the absorption of toxins by glutathione. The Creation of Glutathione Knowing the theory of glutathione is useful but without the correct application of the data it is pointless. Increasing glutathione intracellularly can be done in only a few ways. Using a whey protein designed in such a way to present to the cells the required amino acids in the exact sequence or by nutrients and or foods. The natural way for our body to produce intracellular glutathione is with all natural nutrients. This is also how I recommend an individual increase intracellular glutathione if possible. However, with knowing 50% of the population has the genetic makeup that gets in the way of the body's ability to create glutathione naturally from food, a whey protein may be your best answer. Why? Imagine you have a car that will not start because the battery is low in power. You can give the car a jumpstart and drive down the road but the chances are you will need to keep getting a jumpstart every time you wish to drive. The above example is what is happening when you bypass the natural structure of the body. If you were to fill the battery with water and put it on a slow charge until it was at full power you should not have to rely on a jumpstart again. This example is what should take place within the body regarding the creation of glutathione. Putting the correct nutrients in the body and allowing the body to use the nutrients to eventually manufacture glutathione not only gets those body parts working again but also promotes long-term health. Your body can manufacture glutathione with the correct nutrients. If you have been told it takes one of these whey proteins to manufacture glutathione and that is the only way to do it, someone has lied to you. Immunotec Research, a network marketing company (Multi-level Marketing) and the manufacture of a whey protein called Immunocal has had their attorney contact me regarding statements on this Web Site about their product as well as glutathione. The attorney insisted I take the information down. I asked the simple question: "Tell me what specific point I have made that is not true about glutathione or Immunocal and I will take it off the site immediately." The attorney could not site one example. He did not even try. The main problem I had with Immunocal and their promotion of the product that prompted the call from their attorney were their claims. I discovered the patents they were basing their claims from were not the same product being sold now. Immunocal was still a whey protein but the Immunocal manufacturing procedure had changed dramatically. The entire structure of their product had changed. Within a few months after telling the Immunotec attorney their current product is not the same product they are basing their claim from, Immunotec removed all reference of their earlier patents related to the current Immunocal being sold. I do feel Immunocal is a good whey protein but I do want the reader to know you will need to do your own research on current Immunocal claims and a full research needs to be conducted if the information you are receiving comes from a network marketing professional that sells Immunocal. This includes any doctor that may be making outlandish claims and part of the Immunotec Network Marketing program. If you want to purchase Immunocal, http://www.immunotec.com/JGebhardt sells it at the lowest price I can find. (This Web Site is not affiliated with Immunotec, Immunocal or this distributor) The best whey protein product we have found for increasing intracellular glutathione is Renew Pro. It can be purchased from TRB Health site. Click here (This Web Site does not sell Renew pro) Glutathione as a Detoxicant Supplemental detoxicants become necessary as our environment becomes increasingly polluted. Our food and water sources are contaminated with chemicals. One of our main defenses against pollutants is glutathione, which is present in the liver in high concentrations. Glutathione acts as a detoxifying agent by combining with undesirable substances and ridding the body of them through urine and bile. It is important to note that unless the Colon, Liver and Blood are also detoxified, the benefits of Glutathione as a detoxicant may be minimized. To Get a Little More Technical About Glutathione "Glutathione is a ubiquitous tripeptide molecule, consisting of three amino acids joined together. These are cysteine, glutamic acid and glycine - three of the twenty two amino acids which comprise the building blocks of all known proteins. In general, the amino-end of one amino acid combines with the acid-end of another to form a peptide bond with the elimination of water. Chains of amino acids are called proteins. The sequence of amino acids and the arrangement in space of each peptide bond defines some specific structural features of all proteins and olegopeptides (few amino acids in sequence) that relate to their function." Glutathione (Psychoneurobiology) "Free radicals and oxyradicals have been recognized by psychoneurobiologist as playing an important role in the development and progression of many of these disorders. The brain is particularly susceptible to free radical attack because it generates more oxidative-by-products per gram of tissue than any other organ. The brain's main antioxidant is glutathione- it's importance cannot be overstated." "Oxidative stress and glutathione are important factors in such various disorders as brain injury, neurodegenerative disease, schizophrenia, Down syndrome and other pathologies." Disorders of the brain and nervous system that are linked to oxidative stress. Brain Injury Neurodegenerative Disease Others Brain injury Parkinson's disease Schizophrenia Trauma Alzheimer's dementia Down syndrome Stroke Multiple sclerosis (MS) Tardive dyskinesia Ischemia Lou Gehrig's disease (ALS) Sleep deprivation Toxicity of lead, mercury, etc. Lipofuscinosis (Batten's disease) Huntington's chorea "Many neurological and psychiatric disease processes are characterized by high levels of oxidative stress and free radical formation, as well as abnormalities in glutathione metabolism and antioxidant defenses." Source Dr. Gutman M.D. Glutathione GSH Dr. Perlmutter: "Eighty to ninety percent improve dramatically. It's felt that the mechanism that allows it to work is in increasing the sensitivity to certain receptors to dopamine. Glutathione doesn't raise dopamine levels, but it allows the dopamine in the brain to be more effective. That's not a new idea in medicine. Diabetic drugs work not by increasing insulin, but by increasing the receptors to insulin. Glutathione not only increases sensitivity to dopamine, but also to serotonin, which may explain why many of our depressed PD patients have a remarkable improvement." Increasing glutathione in the body has been proven to be essential in the treatment of disease. Antidepressants and other medications deplete the body and brain of glutathione. Functions of Glutathione Enhancing the Immune System - Your bodies immune activity, involving unimpeded multiplication of lymphocytes and antibody production, requires maintenance of normal levels of glutathione inside the lymphocytes. Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses, pollutants and free radicals. Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job adequately to protect your body against disease. A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as carcinogens and harmful metabolites.
Glutathione