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| Glutathione. What is glutathione, how is
glutathione made and how to safely increase glutathione levels answered on the
Web Site. Glutathione used to treat toxicity, acne, cancer, HIV, allergies,
Alzheimer's disease, cystic fibrosis, diabetes, hepatitis, liver dysfunction and
more.GlutathioneWhat is Glutathione The presence of glutathione is required to maintain the normal function of the immune system. It is known to play a critical role in the multiplication of lymphocytes (the cells that mediate specific immunity) which occurs in the development of an effective immune response. Furthermore, the cells of the immune system produce many oxiradicals as a result of their normal functioning, resulting in a need for higher concentrations of antioxidants than most cells. Glutathione plays a crucial role in fulfilling this requirement. How to Make
Glutathione Naturally Within the Body As an example, asparagus and watermelon will make glutathione. With all of the breaking news regarding glutathione as an antioxidant as well as part of the reason for the development of autism, many supplements are suddenly jumping on the glutathione bandwagon. Glutathione is not new to this Web Site. We have been recommending glutathione for the past 10 years to assist individuals to taper off psychotropic medications. One thing that has been overlooked by many still is the role of glutathione within the liver as well as the role of glutathione transporting a toxin to the liver. There is considerable more to glutathione than having it in the cells. The whey proteins mentioned on this site do make intracellular glutathione. However, like most other things in life, not all things are equal. When you need intracellular glutathione quickly, the best method and safest method is with a whey protein. We have reviewed the top selling whey proteins. One whey protein stands so far above all others it is amazing. To begin, click here (pdf file) and look at the test results comparing the top selling whey proteins. *** When you look at the charts from the link above, keep in mind the Immune Pro and the Renew Pro are also from disease-free, pesticide-free, chemical-free, natural grass pasture fed cows. Hormone treatment-free and Genetically Modified-free. To top it off, the Immune Pro and Renew Pro are lower in price. We recommend the Renew Pro over the Immune Pro. Reason: We have found the Immune Pro is actually a little too strong and the taste is bland. Compliance with the Immune Pro is no where as high as with the Renew Pro. When you want and need intracellular glutathione, nothing compares. You can purchase the Renew Pro from TRB Health at the best price. Additional Glutathione Information The non-essential amino acid homocysteine is produced in the body with the metabolism of the amino acid methionine. Homocysteine is usually broken down into the amino acid cysteine. Cysteine is one of the amino acids needed by the cells to make intracellular glutathione. If your body does not convert homocysteine to cysteine the intracellular glutathione conversion will not take place. The rapid conversion of homocysteine is critical. If conversion takes place too slow, homocysteine will accumulate in the body and damage cell membranes, damage blood vessels, increase the risk of cardiovascular disease, and atherosclerosis. Rapid conversion of homocysteine requires an individual to have adequate amount of vitamin B6, B12, and folate. Over 50% of the population in the world has a genetic defect in the pathway needed to metabolize B6, B12, and folate. Metabolism of homocysteine (sulphur-containing amino acid) is accomplished in the remethylation cycle where vitamin B12 and folic acid are essential coenzymes and degraded to methionine or through transsulfuration, which use as cofactors folate, vitamin B6 and vitamin B12 and is degraded to cystathionine. The physician can check for hyperhomocysteine (higher than normal amount of homocysteine) with a blood test. Many medication side effects, physiological symptomology and other body and mental symptoms can be eliminated with treatment with vitamins B6, B12 and folate. Age is a factor of B6, B12 and folate metabolism despite an individuals DNA. With age, the enzyme needed to metabolize B6, B12 and folate will be depleted and the need to supplement through nutrition increases proportionally. The only way for an individual to receive adequate amount of B6, B12, and folate is with nutrition. The supplemental capsule or tablet form will not metabolize. High levels of homocysteine will be toxic on cells that line the arteries which will make the blood prone to clotting and promote bad cholesterol (LDL) which will be deposited as plaque in blood vessels. Cysteine helps to detoxify toxins and protect the body from radiation damage. Cysteine as well as selenium work hand in hand with vitamin E. Cysteine also needs selenium to be effective. Cysteine will bind with soluble iron, chelates heavy metals, and breaks down mucus in the respiratory tract, beneficial for bronchitis, emphysema, and tuberculosis. Of note: Cysteine as a stand-alone supplement should be avoided due to toxicity. Glutathione - Recap Cysteine is the pre-cursor to glutathione, the body’s natural antioxidant. Glutathione regulates the antioxidant redox state, and allows the body to recycle its store of antioxidants including: vitamin A, C, E and Co-enzyme Q10. Free cysteine in unstable and is readily oxidized producing compounds that could have harmful effects. Glutathione cannot be absorbed by cells and so must be re-synthesized intracellularly. Glutathione is the antioxidant that is prevalent in every cell in the human body. Glutathione is primarily synthesized in the liver where it is abundantly present. 80-90% of the blood that leaves the stomach and intestines passes through the liver. The blood carries important nutrients to the liver where they are metabolized into substances vital to life. In the same way, exogenous toxic substances reach the liver where they are either activated or transformed into less toxic derivatives. Glutathione plays a crucial role in the liver’s biotransformation system. The liver biotransformation system comprises important functions:
The liver uses glutathione to process; alcohol, caffeine, medications, nicotine as an example, to process such substances and remove them from the blood. Cysteine is the limiting factor in glutathione synthesis, ensuring an adequate supply of glutathione helps cleanse the blood of toxins and substances. The role of glutathione and its inter-workings with alcohol and the metabolism has received the attention of scientist for years. With alcohol metabolism using the P 450 enzymes, much of the alcohol studies can be transformed into applicable knowledge with antidepressants and other medications that use the same system. Ethanol and GlutathioneReduced glutathione plays a critical role in the cellular detoxification processes including the metabolism of peroxides, the conjugation with electrophils and the scavenging of the free radicals. The relevance of glutathione in ethanol metabolism consists mainly in compensating for alcohol-related oxidative stress. Oxidative stress is a disturbance in the pro-oxidant/antioxidant balance (increased pro-oxidant levels), which may be achieved by either an enhancement of oxidative reactions leading to the increased formation of reactive oxygen species (ROS) or by a decrease of the antioxidant defense. Whether you are working with alcohol or most medications, both will activate the microsomal Cytochrome P450-dependant enzyme system, especially the subclass CYP2E1, that plays an important role in the liver detoxification. With antidepressants it will usually be with the subclass CYP2D6 or the CYP2C9 pathways. Glutathione (GSH) will be depleted within the cells and liver and also in other organs in the body due to the absorption of toxins by glutathione. The Creation of Glutathione Knowing the theory of glutathione is useful but without the correct application of the data it is pointless. Increasing glutathione intracellularly can be done in only a few ways. Using a whey protein designed in such a way to present to the cells the required amino acids in the exact sequence or by nutrients and or foods. The natural way for our body to produce intracellular glutathione is with all natural nutrients. This is also how I recommend an individual increase intracellular glutathione if possible. However, with knowing 50% of the population has the genetic makeup that gets in the way of the body's ability to create glutathione naturally from food, a whey protein may be your best answer. Why?Imagine you have a car that will not start because the battery is low in power. You can give the car a jumpstart and drive down the road but the chances are you will need to keep getting a jumpstart every time you wish to drive. The above example is what is happening when you bypass the natural structure of the body. If you were to fill the battery with water and put it on a slow charge until it was at full power you should not have to rely on a jumpstart again. This example is what should take place within the body regarding the creation of glutathione. Putting the correct nutrients in the body and allowing the body to use the nutrients to eventually manufacture glutathione not only gets those body parts working again but also promotes long-term health. Your body can manufacture glutathione with the correct nutrients. If you have been told it takes one of these whey proteins to manufacture glutathione and that is the only way to do it, someone has lied to you. Immunotec Research, a network marketing company (Multi-level Marketing) and the manufacture of a whey protein called Immunocal has had their attorney contact me regarding statements on this Web Site about their product as well as glutathione. The attorney insisted I take the information down. I asked the simple question: "Tell me what specific point I have made that is not true about glutathione or Immunocal and I will take it off the site immediately." The attorney could not site one example. He did not even try. The main problem I had with Immunocal and their promotion of the product that prompted the call from their attorney were their claims. I discovered the patents they were basing their claims from were not the same product being sold now. Immunocal was still a whey protein but the Immunocal manufacturing procedure had changed dramatically. The entire structure of their product had changed. Within a few months after telling the Immunotec attorney their current product is not the same product they are basing their claim from, Immunotec removed all reference of their earlier patents related to the current Immunocal being sold. I do feel Immunocal is a good whey protein but I do want the reader to know you will need to do your own research on current Immunocal claims and a full research needs to be conducted if the information you are receiving comes from a network marketing professional that sells Immunocal. This includes any doctor that may be making outlandish claims and part of the Immunotec Network Marketing program. If you want to purchase Immunocal, http://www.immunotec.com/JGebhardt sells it at the lowest price I can find. (This Web Site is not affiliated with Immunotec, Immunocal or this distributor) The best whey protein product we have found for increasing intracellular glutathione is Renew Pro. It can be purchased from TRB Health site. Click here (This Web Site does not sell Renew pro) Glutathione as a Detoxicant To Get a Little More Technical About Glutathione Glutathione (Psychoneurobiology) "Free radicals and oxyradicals have been recognized by psychoneurobiologist as playing an important role in the development and progression of many of these disorders. The brain is particularly susceptible to free radical attack because it generates more oxidative-by-products per gram of tissue than any other organ. The brain's main antioxidant is glutathione- it's importance cannot be overstated." "Oxidative stress and glutathione are important factors in such various disorders as brain injury, neurodegenerative disease, schizophrenia, Down syndrome and other pathologies." Disorders of the brain and nervous system that are linked to oxidative stress
"Many neurological and psychiatric disease processes are characterized by high levels of oxidative stress and free radical formation, as well as abnormalities in glutathione metabolism and antioxidant defenses." Source Dr. Gutman M.D. Glutathione GSH Dr. Perlmutter: "Eighty to ninety percent improve dramatically. It's felt that the mechanism that allows it to work is in increasing the sensitivity to certain receptors to dopamine. Glutathione doesn't raise dopamine levels, but it allows the dopamine in the brain to be more effective. That's not a new idea in medicine. Diabetic drugs work not by increasing insulin, but by increasing the receptors to insulin. Glutathione not only increases sensitivity to dopamine, but also to serotonin, which may explain why many of our depressed PD patients have a remarkable improvement." Increasing glutathione in the body has been proven to be essential in the treatment of disease. Antidepressants and other medications deplete the body and brain of glutathione. Functions of Glutathione Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses, pollutants and free radicals. Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job adequately to protect your body against disease. A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as carcinogens and harmful metabolites.
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